Club foot: a twin study Export

@article{146, abstract = {The aetiology of congenital club foot is unclear. Although studies on populations, families and twins suggest a genetic component, the mode of inheritance does not comply with distinctive patterns. The Odense-based Danish Twin Registry contains data on all 73,000 twin pairs born in Denmark over the last 130 years. In 2002 all 46 418 twins born between 1931 and 1982 received a 17-page questionnaire, one question of which was 'Were you born with club foot?' A total of 94 twins answered 'Yes', giving an overall self-reported prevalence of congenital club foot of 0.0027 (95\% confidence interval (CI) 0.0022 to 0.0034). We identified 55 complete twin pairs, representing 12 monozygotic, 22 dizygotic same sex (DZss), 18 dizygotic other sex (DZos) and three unclassified. Two monozygotic and 2 DZss pairs were concordant. The pairwise concordance was 0.17 (95\% CI 0.02 to 0.48) for monozygotic, 0.09 (95\% CI 0.01 to 0.32) for DZss and 0.05 (95\% CI 0.006 to 0.18) for all dizygotic (DZtot) twins. We have found evidence of a genetic component in congenital club foot, although non-genetic factors must play a predominant role.}, address = {Department of Orthopaedic Surgery, University Hospital of Odense, SDR Boulevard 29, DK-5000 Odense C, Denmark. Vilhelm.Engell@stofanet.dk}, author = {Engell, V. and Damborg, F. and Andersen, M. and Kyvik, K. O. and Thomsen, K.}, citeulike-article-id = {2867683}, comment = {PUBM: Print; JID: 0375355; ppublish}, isbn = {0301-620X (Print)}, journal = {Journal of Bone and Joint Surgery. British volume}, keywords = {clubfoot, epidemiology, genetics, journal-club-2006, twins}, number = {3}, pages = {374--376}, posted-at = {2008-06-05 21:54:51}, priority = {2}, title = {Club foot: a twin study}, volume = {88} }

TY - JOUR ID - 146 L3 - citeulike-article-id:2867683 N2 - The aetiology of congenital club foot is unclear. Although studies on populations, families and twins suggest a genetic component, the mode of inheritance does not comply with distinctive patterns. The Odense-based Danish Twin Registry contains data on all 73,000 twin pairs born in Denmark over the last 130 years. In 2002 all 46 418 twins born between 1931 and 1982 received a 17-page questionnaire, one question of which was 'Were you born with club foot?' A total of 94 twins answered 'Yes', giving an overall self-reported prevalence of congenital club foot of 0.0027 (95% confidence interval (CI) 0.0022 to 0.0034). We identified 55 complete twin pairs, representing 12 monozygotic, 22 dizygotic same sex (DZss), 18 dizygotic other sex (DZos) and three unclassified. Two monozygotic and 2 DZss pairs were concordant. The pairwise concordance was 0.17 (95% CI 0.02 to 0.48) for monozygotic, 0.09 (95% CI 0.01 to 0.32) for DZss and 0.05 (95% CI 0.006 to 0.18) for all dizygotic (DZtot) twins. We have found evidence of a genetic component in congenital club foot, although non-genetic factors must play a predominant role. IS - 3 JF - Journal of Bone and Joint Surgery. British volume SN - 0301-620X (Print) AD - Department of Orthopaedic Surgery, University Hospital of Odense, SDR Boulevard 29, DK-5000 Odense C, Denmark. Vilhelm.Engell@stofanet.dk EP - 376 TI - Club foot: a twin study VL - 88 SP - 374 KW - clubfoot KW - epidemiology KW - genetics KW - journal-club-2006 KW - twins N1 - PUBM: Print; JID: 0375355; ppublish AU - Engell, V AU - Damborg, F AU - Andersen, M AU - Kyvik, KO AU - Thomsen, K ER -