Triggers and tricks of Plasmodium sexual development Export

@article{kooij:plasmodium, abstract = {Irrespective of the tremendous suffering caused by malaria, a Plasmodium infection by pathogenic blood stages is only transient and an obligate step toward the Anopheles vector where sexual reproduction and genetic recombination of the unicellular parasite takes place. Recent expression profiling studies identified the molecular make-up of female and male gametocytes. Differential promoters and translational repression through mRNA binding by a female-specific helicase help to fine-tune the expression of these sexual stage-specific genes. However, we are only just beginning to discover the triggers that initiate gametocytogenesis and the developmental programs that drive sexual development.}, address = {Department of Parasitology, Heidelberg University School of Medicine, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany. taco.kooij@med.uni-heidelberg.de}, author = {Kooij, T. and Matuschewski, K.}, citeulike-article-id = {2423616}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.mib.2007.09.015}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1369527407001403}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18006365}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18006365}, doi = {10.1016/j.mib.2007.09.015}, issn = {13695274}, journal = {Current Opinion in Microbiology}, keywords = {network, plasmodium}, month = {December}, number = {6}, pages = {547--553}, posted-at = {2009-04-15 20:10:17}, priority = {2}, title = {Triggers and tricks of Plasmodium sexual development}, url = {http://dx.doi.org/10.1016/j.mib.2007.09.015}, volume = {10}, year = {2007} }

TY - JOUR ID - kooij:plasmodium L3 - citeulike-article-id:2423616 N2 - Irrespective of the tremendous suffering caused by malaria, a Plasmodium infection by pathogenic blood stages is only transient and an obligate step toward the Anopheles vector where sexual reproduction and genetic recombination of the unicellular parasite takes place. Recent expression profiling studies identified the molecular make-up of female and male gametocytes. Differential promoters and translational repression through mRNA binding by a female-specific helicase help to fine-tune the expression of these sexual stage-specific genes. However, we are only just beginning to discover the triggers that initiate gametocytogenesis and the developmental programs that drive sexual development. IS - 6 JF - Current Opinion in Microbiology SN - 13695274 AD - Department of Parasitology, Heidelberg University School of Medicine, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany. taco.kooij@med.uni-heidelberg.de EP - 553 TI - Triggers and tricks of Plasmodium sexual development VL - 10 SP - 547 KW - network KW - plasmodium AU - Kooij, T AU - Matuschewski, K PY - 2007/12// UR - http://dx.doi.org/10.1016/j.mib.2007.09.015 ER -