Effect of capsaicin upon afferent and efferent mechanisms of nociception and temperature regulation in birds. Export

@article{citeulike:1132951, abstract = {(1) Acute capsaicin effects on nociception in the conscious chicken were tested by close arterial injection. The threshold dose to elicit nocifensive and autonomic responses was 50 micrograms, i.e., two to three orders of magnitude higher than in mammals but four times lower than in pigeons. (2) Foot withdrawal from hot water remained unchanged after capsaicin was injected either intravenously in the chicken at a cumulative dose of 600 mg/kg or perineurally at a dose of 100 micrograms into the sciatic nerve of pigeons. (3) Temperature regulation and body temperature in the chicken were not affected by subcutaneous injection of capsaicin, but intravenous infusion at rates of 2-5 or 10-13 mg X min-1 X kg-1 transiently lowered body temperature by 1.5 degrees C and stimulated panting and sometimes vasodilatation of the comb. Repeated capsaicin infusion produced temporary tachyphylaxia but no permanent desensitization. (4) A cumulative dose of 1 g/kg body weight capsaicin reduced the relationship between breathing frequency and respiratory evaporative heat loss in the duck. This deficit was compensated by more pronounced panting and, thus, did not indicate any impairment of temperature regulation. (5) Injection of capsaicin into the sciatic nerve depleted substance P in the dorsal horn of rats. Similar treatment in pigeons caused an increase of substance P immunoreactivity in the dorsal horn. (6) The effects of high capsaicin doses in birds indicate only low susceptibility of afferent neural mechanisms. Some of the effects may be due to a capsaicin action upon efferent neural mechanisms.}, author = {Sann, H. and Harti, G. and Pierau, F. K. and Simon, E.}, citeulike-article-id = {1132951}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/2441835}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=2441835}, comment = {PubMed画面プリント}, issn = {0008-4212}, journal = {Can J Physiol Pharmacol}, keywords = {bird, capsaicin, chicken}, month = {June}, number = {6}, pages = {1347--1354}, posted-at = {2007-03-01 03:16:02}, priority = {2}, title = {Effect of capsaicin upon afferent and efferent mechanisms of nociception and temperature regulation in birds.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/2441835}, volume = {65}, year = {1987} }

TY - JOUR ID - citeulike:1132951 L3 - citeulike-article-id:1132951 N2 - (1) Acute capsaicin effects on nociception in the conscious chicken were tested by close arterial injection. The threshold dose to elicit nocifensive and autonomic responses was 50 micrograms, i.e., two to three orders of magnitude higher than in mammals but four times lower than in pigeons. (2) Foot withdrawal from hot water remained unchanged after capsaicin was injected either intravenously in the chicken at a cumulative dose of 600 mg/kg or perineurally at a dose of 100 micrograms into the sciatic nerve of pigeons. (3) Temperature regulation and body temperature in the chicken were not affected by subcutaneous injection of capsaicin, but intravenous infusion at rates of 2-5 or 10-13 mg X min-1 X kg-1 transiently lowered body temperature by 1.5 degrees C and stimulated panting and sometimes vasodilatation of the comb. Repeated capsaicin infusion produced temporary tachyphylaxia but no permanent desensitization. (4) A cumulative dose of 1 g/kg body weight capsaicin reduced the relationship between breathing frequency and respiratory evaporative heat loss in the duck. This deficit was compensated by more pronounced panting and, thus, did not indicate any impairment of temperature regulation. (5) Injection of capsaicin into the sciatic nerve depleted substance P in the dorsal horn of rats. Similar treatment in pigeons caused an increase of substance P immunoreactivity in the dorsal horn. (6) The effects of high capsaicin doses in birds indicate only low susceptibility of afferent neural mechanisms. Some of the effects may be due to a capsaicin action upon efferent neural mechanisms. IS - 6 JF - Can J Physiol Pharmacol SN - 0008-4212 EP - 1354 TI - Effect of capsaicin upon afferent and efferent mechanisms of nociception and temperature regulation in birds. VL - 65 SP - 1347 KW - bird KW - capsaicin KW - chicken N1 - PubMed画面プリント AU - Sann, H AU - Harti, G AU - Pierau, FK AU - Simon, E PY - 1987/06// UR - http://view.ncbi.nlm.nih.gov/pubmed/2441835 ER -