Electron microscopic demonstration of nick end-labeled DNA fragments during capsaicin-induced apoptosis of trigeminal primary neurons in neonatal rats. Export

@article{citeulike:1140270, abstract = {DNA fragmentation was induced in the trigeminal ganglion of newborn rats by subcutaneous capsaicin injection (50 mg/kg). Twenty-four hours later, numerous roundish profiles were intensely labeled by both a DNA polymerase I-mediated nick translation method and a terminal transferase-mediated tailing method. Direct electron microscopic examination of labeled profiles indicated that the labeled profiles were neurons at earlier stages of apoptosis. DNA fragmentation signal was first detected in the nucleoplasm and later spread to the cytoplasm. The cell finally disintegrated forming many small apoptotic bodies. DNA fragmentation signal in the apoptotic bodies was readily labeled by the tailing but not the translation method.}, address = {Department of Oral Anatomy II, Okayama University Dental School, 2-5-1 Shikata-cho, Okayama 700-8525, Japan.}, author = {Sugimoto, T. and Takeyama, A. and Xiao, C. and Takano-Yamamoto, T. and Ichikawa, H.}, citeulike-article-id = {1140270}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/9914448}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=9914448}, comment = {Capsaicin CAP-SEN-Neu Box}, day = {6}, issn = {0006-8993}, journal = {Brain Res}, keywords = {apoptosis, capsaicin}, month = {February}, number = {1}, pages = {147--152}, posted-at = {2007-03-05 00:45:31}, priority = {2}, title = {Electron microscopic demonstration of nick end-labeled DNA fragments during capsaicin-induced apoptosis of trigeminal primary neurons in neonatal rats.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/9914448}, volume = {818}, year = {1999} }

TY - JOUR ID - citeulike:1140270 L3 - citeulike-article-id:1140270 N2 - DNA fragmentation was induced in the trigeminal ganglion of newborn rats by subcutaneous capsaicin injection (50 mg/kg). Twenty-four hours later, numerous roundish profiles were intensely labeled by both a DNA polymerase I-mediated nick translation method and a terminal transferase-mediated tailing method. Direct electron microscopic examination of labeled profiles indicated that the labeled profiles were neurons at earlier stages of apoptosis. DNA fragmentation signal was first detected in the nucleoplasm and later spread to the cytoplasm. The cell finally disintegrated forming many small apoptotic bodies. DNA fragmentation signal in the apoptotic bodies was readily labeled by the tailing but not the translation method. IS - 1 JF - Brain Res SN - 0006-8993 AD - Department of Oral Anatomy II, Okayama University Dental School, 2-5-1 Shikata-cho, Okayama 700-8525, Japan. EP - 152 TI - Electron microscopic demonstration of nick end-labeled DNA fragments during capsaicin-induced apoptosis of trigeminal primary neurons in neonatal rats. VL - 818 SP - 147 KW - apoptosis KW - capsaicin N1 - Capsaicin CAP-SEN-Neu Box AU - Sugimoto, T AU - Takeyama, A AU - Xiao, C AU - Takano-Yamamoto, T AU - Ichikawa, H PY - 1999/02/06/ UR - http://view.ncbi.nlm.nih.gov/pubmed/9914448 ER -