Capsaicin induces apoptosis and terminal differentiation in human glioma A172 cells Export

@article{citeulike:2718350, abstract = {Capsaicin (8-methyl-N-vanillyl-6-nonenamide), the major pungent ingredient of red pepper, has been reported to possess anti-carcinogenic and anti-mutagenic activities. In this study, the effects of capsaicin on human glioblastoma A172 cells were investigated. Treatment of A172 cells with capsaicin inhibited cell growth and induced apoptosis through down-regulation of Bcl-2 and activation of caspase-3. Interestingly, synergistic induction of morphological alternation was observed when A172 cells were treated with capsaicin. A double immunostaining analysis indicated that capsaicin stimulated terminal differentiation predominantly to astrocyte-like cells. Moreover, capsaicin increased the transcription levels of glial fibrillary acidic protein (GFAP) and neuronal microtubule-associated protein 2ab (MAP2ab). These results demonstrated that capsaicin inhibits A172 cell growth through apoptosis and terminal differentiation. Consequently, this research may provide further support for capsaicin-based anti-tumor therapies and consideration should be given to developing capsaicin for use in chemotherapy for malignant human glioblastoma.}, author = {Gil, Young-Gi and Kang, Mi-Kyung}, citeulike-article-id = {2718350}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.lfs.2008.02.020}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6T99-4S1C2S4-1/1/0c90745ef14e7532bf2ba5fa05eba928}, day = {7}, doi = {10.1016/j.lfs.2008.02.020}, journal = {Life Sciences}, keywords = {apoptosis, capsaicin, glioma}, month = {May}, number = {19-20}, pages = {997--1003}, posted-at = {2008-04-25 13:48:12}, priority = {2}, title = {Capsaicin induces apoptosis and terminal differentiation in human glioma A172 cells}, url = {http://dx.doi.org/10.1016/j.lfs.2008.02.020}, volume = {82}, year = {2008} }

TY - JOUR ID - citeulike:2718350 L3 - citeulike-article-id:2718350 N2 - Capsaicin (8-methyl-N-vanillyl-6-nonenamide), the major pungent ingredient of red pepper, has been reported to possess anti-carcinogenic and anti-mutagenic activities. In this study, the effects of capsaicin on human glioblastoma A172 cells were investigated. Treatment of A172 cells with capsaicin inhibited cell growth and induced apoptosis through down-regulation of Bcl-2 and activation of caspase-3. Interestingly, synergistic induction of morphological alternation was observed when A172 cells were treated with capsaicin. A double immunostaining analysis indicated that capsaicin stimulated terminal differentiation predominantly to astrocyte-like cells. Moreover, capsaicin increased the transcription levels of glial fibrillary acidic protein (GFAP) and neuronal microtubule-associated protein 2ab (MAP2ab). These results demonstrated that capsaicin inhibits A172 cell growth through apoptosis and terminal differentiation. Consequently, this research may provide further support for capsaicin-based anti-tumor therapies and consideration should be given to developing capsaicin for use in chemotherapy for malignant human glioblastoma. IS - 19-20 JF - Life Sciences EP - 1003 TI - Capsaicin induces apoptosis and terminal differentiation in human glioma A172 cells VL - 82 SP - 997 KW - apoptosis KW - capsaicin KW - glioma AU - Gil, Young-Gi AU - Kang, Mi-Kyung PY - 2008/05/07/ UR - http://dx.doi.org/10.1016/j.lfs.2008.02.020 ER -