Primary afferent dendrite degeneration as a cause of tinnitus. Export

@article{citeulike:1343034, abstract = {Chronic tinnitus affects millions of people, but the mechanisms responsible for the development of this abnormal sensory state remain poorly understood. This study examined the type and extent of cochlear damage that occurs after acoustic trauma sufficient to induce chronic tinnitus in rats. Tinnitus was evaluated by using a conditioned suppression method of behavioral testing. Cochlear damage was assessed 6 months after acoustic trauma. There was minimal loss of inner and outer hair cells in the exposed cochleas of subjects demonstrating evidence of tinnitus. However, a significant loss of large-diameter fibers in the osseous spiral lamina of exposed cochleas of trauma subjects was observed. The significance of this finding in the context of a model of tinnitus is discussed. (c) 2007 Wiley-Liss, Inc.}, address = {Division of Otolaryngology Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, Illinois.}, author = {Bauer, C. A. and Brozoski, T. J. and Myers, K.}, citeulike-article-id = {1343034}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/jnr.21259}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17393482}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17393482}, comment = {I don't really understand how you can tell if a rat has tinnitus- however the psychophysical testing in these rats correlated with the degree of hair cell loss and loss of primary afferent fibres...}, day = {15}, doi = {10.1002/jnr.21259}, issn = {0360-4012}, journal = {J Neurosci Res}, keywords = {afferent, degeneration, dendrite, sensory, tinnitus}, month = {May}, number = {7}, pages = {1489--1498}, posted-at = {2007-05-30 15:21:28}, priority = {0}, title = {Primary afferent dendrite degeneration as a cause of tinnitus.}, url = {http://dx.doi.org/10.1002/jnr.21259}, volume = {85}, year = {2007} }

TY - JOUR ID - citeulike:1343034 L3 - citeulike-article-id:1343034 N2 - Chronic tinnitus affects millions of people, but the mechanisms responsible for the development of this abnormal sensory state remain poorly understood. This study examined the type and extent of cochlear damage that occurs after acoustic trauma sufficient to induce chronic tinnitus in rats. Tinnitus was evaluated by using a conditioned suppression method of behavioral testing. Cochlear damage was assessed 6 months after acoustic trauma. There was minimal loss of inner and outer hair cells in the exposed cochleas of subjects demonstrating evidence of tinnitus. However, a significant loss of large-diameter fibers in the osseous spiral lamina of exposed cochleas of trauma subjects was observed. The significance of this finding in the context of a model of tinnitus is discussed. (c) 2007 Wiley-Liss, Inc. IS - 7 JF - J Neurosci Res SN - 0360-4012 AD - Division of Otolaryngology Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, Illinois. EP - 1498 TI - Primary afferent dendrite degeneration as a cause of tinnitus. VL - 85 SP - 1489 KW - afferent KW - degeneration KW - dendrite KW - sensory KW - tinnitus N1 - I don't really understand how you can tell if a rat has tinnitus- however the psychophysical testing in these rats correlated with the degree of hair cell loss and loss of primary afferent fibres... AU - Bauer, CA AU - Brozoski, TJ AU - Myers, K PY - 2007/05/15/ UR - http://dx.doi.org/10.1002/jnr.21259 ER -