Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency. Export

@article{citeulike:1343312, abstract = {Vitamin E deficiency causes a neurological disorder characterised by sensory loss, ataxia and retinitis pigmentosa due to free radical mediated neuronal damage. Symptomatic vitamin E deficiency has been reported in genetic defects of the vitamin E transport protein and in malabsorption complicating cholestasis, abetalipoproteinaemia, celiac disease, cystic fibrosis and small bowel resection. There are no reports to date of vitamin E deficiency in patients with primary immunodeficiencies. We describe two CVID patients with the associated enteropathy who developed neurological disease because of vitamin E deficiency, suggesting a possible predisposition to developing this complication. We recommend that all CVID patients with evidence of an enteropathy be screened for vitamin E deficiency, as early detection and consequent treatment may prevent, halt or reverse the neurological sequelae.}, address = {Department of Immunology, Oxford Radcliffe Hospitals, John Radcliffe Campus, Headington, Oxford OX3 9DU, UK.}, author = {Aslam, A. and Misbah, S. A. and Talbot, K. and Chapel, H.}, citeulike-article-id = {1343312}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.clim.2004.02.001}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15207778}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15207778}, comment = {2 cases of people with neurological problems and vitamin e deficiency and improvements after vitamin e supplementation. Vitamin E deficiency causes a neurological disorder characterised by sensory loss. It arises as a consequence of chronic cholestasis, abetalipoproteinaemia, celiac disease or cystic fibrosis.}, doi = {10.1016/j.clim.2004.02.001}, issn = {1521-6616}, journal = {Clin Immunol}, keywords = {case, deficiency, degeneration, e, reports, sensory, vitamin}, month = {July}, number = {1}, pages = {24--29}, posted-at = {2007-05-30 15:53:16}, priority = {0}, title = {Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency.}, url = {http://dx.doi.org/10.1016/j.clim.2004.02.001}, volume = {112}, year = {2004} }

TY - JOUR ID - citeulike:1343312 L3 - citeulike-article-id:1343312 N2 - Vitamin E deficiency causes a neurological disorder characterised by sensory loss, ataxia and retinitis pigmentosa due to free radical mediated neuronal damage. Symptomatic vitamin E deficiency has been reported in genetic defects of the vitamin E transport protein and in malabsorption complicating cholestasis, abetalipoproteinaemia, celiac disease, cystic fibrosis and small bowel resection. There are no reports to date of vitamin E deficiency in patients with primary immunodeficiencies. We describe two CVID patients with the associated enteropathy who developed neurological disease because of vitamin E deficiency, suggesting a possible predisposition to developing this complication. We recommend that all CVID patients with evidence of an enteropathy be screened for vitamin E deficiency, as early detection and consequent treatment may prevent, halt or reverse the neurological sequelae. IS - 1 JF - Clin Immunol SN - 1521-6616 AD - Department of Immunology, Oxford Radcliffe Hospitals, John Radcliffe Campus, Headington, Oxford OX3 9DU, UK. EP - 29 TI - Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency. VL - 112 SP - 24 KW - case KW - deficiency KW - degeneration KW - e KW - reports KW - sensory KW - vitamin N1 - 2 cases of people with neurological problems and vitamin e deficiency and improvements after vitamin e supplementation. Vitamin E deficiency causes a neurological disorder characterised by sensory loss. It arises as a consequence of chronic cholestasis, abetalipoproteinaemia, celiac disease or cystic fibrosis. AU - Aslam, A AU - Misbah, SA AU - Talbot, K AU - Chapel, H PY - 2004/07// UR - http://dx.doi.org/10.1016/j.clim.2004.02.001 ER -