Evidence that the Rate of Wallerian Degeneration is Controlled by a Single Autosomal Dominant Gene. Export

@article{citeulike:1942845, abstract = {In a substrain of C57BL mice, C57BL/Ola, Wallerian degeneration in the distal segment of the severed sciatic nerve is extremely slow when compared to other mice. Despite this very slow degeneration in the distal segment regeneration of the motor nerves is not impaired. From suitable genetic outcrosses and backcrosses, the authors provide evidence that the rate of Wallerian degeneration in this strain is controlled by a single autosomal gene product. The authors have also shown that the rate of degeneration, in C57BL/Ola mice, is influenced by the environment in which the animals were bred and housed. Wallerian degeneration in the sciatic nerves of mice raised in isolators is slower than in those raised in a conventional animal house. This strain of mouse may prove to be of value in the understanding of nerve degeneration and regeneration.}, address = {Department of Experimental Psychology.}, author = {Perry, V. H. H. and Lunn, E. R. R. and Brown, M. C. C. and Cahusac, S. and Gordon, S.}, citeulike-article-id = {1942845}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12106028}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12106028}, issn = {0953-816X}, journal = {Eur J Neurosci}, keywords = {gene, mapping, wlds}, number = {5}, pages = {408--413}, posted-at = {2007-11-20 10:35:40}, priority = {2}, title = {Evidence that the Rate of Wallerian Degeneration is Controlled by a Single Autosomal Dominant Gene.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12106028}, volume = {2}, year = {1990} }

TY - JOUR ID - citeulike:1942845 L3 - citeulike-article-id:1942845 N2 - In a substrain of C57BL mice, C57BL/Ola, Wallerian degeneration in the distal segment of the severed sciatic nerve is extremely slow when compared to other mice. Despite this very slow degeneration in the distal segment regeneration of the motor nerves is not impaired. From suitable genetic outcrosses and backcrosses, the authors provide evidence that the rate of Wallerian degeneration in this strain is controlled by a single autosomal gene product. The authors have also shown that the rate of degeneration, in C57BL/Ola mice, is influenced by the environment in which the animals were bred and housed. Wallerian degeneration in the sciatic nerves of mice raised in isolators is slower than in those raised in a conventional animal house. This strain of mouse may prove to be of value in the understanding of nerve degeneration and regeneration. IS - 5 JF - Eur J Neurosci SN - 0953-816X AD - Department of Experimental Psychology. EP - 413 TI - Evidence that the Rate of Wallerian Degeneration is Controlled by a Single Autosomal Dominant Gene. VL - 2 SP - 408 KW - gene KW - mapping KW - wlds AU - Perry, V. H. AU - Lunn, E. R. AU - Brown, M. C. AU - Cahusac, S. AU - Gordon, S. PY - 1990/// UR - http://view.ncbi.nlm.nih.gov/pubmed/12106028 ER -