Physiological characterization of Taxol-induced large-fiber sensory neuropathy in the rat. Export

@article{citeulike:3205010, abstract = {The cancer chemotherapeutic agent Taxol (paclitaxel) causes a dose-related peripheral neuropathy in humans. We produced a dose-dependent large-fiber sensory neuropathy, without detrimental effects on general health, in mature rats by using two intravenous injections 3 days apart. Tests of other dosing schedules demonstrated the dependence of the severity of the neuropathy and of animal health on both the dose and the frequency of dosing. Pathologically, severe axonal degeneration and hypomyelination were observed in sections of dorsal roots, whereas ventral roots remained intact. Electrophysiologically, H-wave amplitudes in the hindlimb and amplitudes of predominantly sensory compound nerve action potentials in the tail were reduced. These effects persisted for at least 4 months after treatment. Motor amplitudes were not affected, but both motor and sensory conduction velocities decreased. The ability of rats to remain balanced on a narrow beam was impaired, indicating proprioceptive deficits. Muscle strength, measured by hindlimb and forelimb grip strength, and heat nociception, measured by tail-flick and hindlimb withdrawal tests, were not affected by Taxol. This model of Taxol-induced neuropathy in mature rats, with minimal effects on general health, parallels closely the clinical syndrome observed after Taxol treatment in humans.}, address = {Regeneron Pharmaceuticals, Inc, Tarrytown, NY 10591, USA.}, author = {Cliffer, K. D. and Siuciak, J. A. and Carson, S. R. and Radley, H. E. and Park, J. S. and Lewis, D. R. and Zlotchenko, E. and Nguyen, T. and Garcia, K. and Tonra, J. R. and Stambler, N. and Cedarbaum, J. M. and Bodine, S. C. and Lindsay, R. M. and DiStefano, P. S.}, citeulike-article-id = {3205010}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/ana.410430111}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/9450768}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=9450768}, doi = {10.1002/ana.410430111}, issn = {0364-5134}, journal = {Annals of neurology}, keywords = {animal, clinical, model, neuropathy, sensory, taxol}, month = {January}, number = {1}, pages = {46--55}, posted-at = {2008-09-08 13:19:47}, priority = {2}, title = {Physiological characterization of Taxol-induced large-fiber sensory neuropathy in the rat.}, url = {http://dx.doi.org/10.1002/ana.410430111}, volume = {43}, year = {1998} }

TY - JOUR ID - citeulike:3205010 L3 - citeulike-article-id:3205010 N2 - The cancer chemotherapeutic agent Taxol (paclitaxel) causes a dose-related peripheral neuropathy in humans. We produced a dose-dependent large-fiber sensory neuropathy, without detrimental effects on general health, in mature rats by using two intravenous injections 3 days apart. Tests of other dosing schedules demonstrated the dependence of the severity of the neuropathy and of animal health on both the dose and the frequency of dosing. Pathologically, severe axonal degeneration and hypomyelination were observed in sections of dorsal roots, whereas ventral roots remained intact. Electrophysiologically, H-wave amplitudes in the hindlimb and amplitudes of predominantly sensory compound nerve action potentials in the tail were reduced. These effects persisted for at least 4 months after treatment. Motor amplitudes were not affected, but both motor and sensory conduction velocities decreased. The ability of rats to remain balanced on a narrow beam was impaired, indicating proprioceptive deficits. Muscle strength, measured by hindlimb and forelimb grip strength, and heat nociception, measured by tail-flick and hindlimb withdrawal tests, were not affected by Taxol. This model of Taxol-induced neuropathy in mature rats, with minimal effects on general health, parallels closely the clinical syndrome observed after Taxol treatment in humans. IS - 1 JF - Annals of neurology SN - 0364-5134 AD - Regeneron Pharmaceuticals, Inc, Tarrytown, NY 10591, USA. EP - 55 TI - Physiological characterization of Taxol-induced large-fiber sensory neuropathy in the rat. VL - 43 SP - 46 KW - animal KW - clinical KW - model KW - neuropathy KW - sensory KW - taxol AU - Cliffer, KD AU - Siuciak, JA AU - Carson, SR AU - Radley, HE AU - Park, JS AU - Lewis, DR AU - Zlotchenko, E AU - Nguyen, T AU - Garcia, K AU - Tonra, JR AU - Stambler, N AU - Cedarbaum, JM AU - Bodine, SC AU - Lindsay, RM AU - DiStefano, PS PY - 1998/01// UR - http://dx.doi.org/10.1002/ana.410430111 ER -