Beyond apoptosis: nonapoptotic cell death in physiology and disease. Export

@article{citeulike:3251935, abstract = {Apoptosis is a morphologically defined form of programmed cell death (PCD) that is mediated by the activation of members of the caspase family. Analysis of death-receptor signaling in lymphocytes has revealed that caspase-dependent signaling pathways are also linked to cell death by nonapoptotic mechanisms, indicating that apoptosis is not the only form of PCD. Under physiological and pathological conditions, cells demonstrate a high degree of flexibility in cell-death responses, as is reflected in the existence of a variety of mechanisms, including necrosis-like PCD, autophagy (or type II PCD), and accidental necrosis. In this review, we discuss recent data suggesting that canonical apoptotic pathways, including death-receptor signaling, control caspase-dependent and -independent cell-death pathways.}, address = {Instituto de Ciencias Biom\'{e}dicas, Universidad de Chile, Santiago, Chile.}, author = {Hetz, C. A. and Torres, V. and Quest, A. F.}, citeulike-article-id = {3251935}, citeulike-linkout-0 = {http://dx.doi.org/10.1139/o05-065}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16234846}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16234846}, doi = {10.1139/o05-065}, issn = {0829-8211}, journal = {Biochemistry and cell biology = Biochimie et biologie cellulaire}, keywords = {apoptosis, cell, death, necrosis, programmed, review}, month = {October}, number = {5}, pages = {579--588}, posted-at = {2008-09-13 15:39:26}, priority = {5}, title = {Beyond apoptosis: nonapoptotic cell death in physiology and disease.}, url = {http://dx.doi.org/10.1139/o05-065}, volume = {83}, year = {2005} }

TY - JOUR ID - citeulike:3251935 L3 - citeulike-article-id:3251935 N2 - Apoptosis is a morphologically defined form of programmed cell death (PCD) that is mediated by the activation of members of the caspase family. Analysis of death-receptor signaling in lymphocytes has revealed that caspase-dependent signaling pathways are also linked to cell death by nonapoptotic mechanisms, indicating that apoptosis is not the only form of PCD. Under physiological and pathological conditions, cells demonstrate a high degree of flexibility in cell-death responses, as is reflected in the existence of a variety of mechanisms, including necrosis-like PCD, autophagy (or type II PCD), and accidental necrosis. In this review, we discuss recent data suggesting that canonical apoptotic pathways, including death-receptor signaling, control caspase-dependent and -independent cell-death pathways. IS - 5 JF - Biochemistry and cell biology = Biochimie et biologie cellulaire SN - 0829-8211 AD - Instituto de Ciencias Biomédicas, Universidad de Chile, Santiago, Chile. EP - 588 TI - Beyond apoptosis: nonapoptotic cell death in physiology and disease. VL - 83 SP - 579 KW - apoptosis KW - cell KW - death KW - necrosis KW - programmed KW - review AU - Hetz, CA AU - Torres, V AU - Quest, AF PY - 2005/10// UR - http://dx.doi.org/10.1139/o05-065 ER -