Axons and synaptic boutons are highly dynamic in adult visual cortex. Export

@article{citeulike:3317379, abstract = {While recent studies of synaptic stability in adult cerebral cortex have focused on dendrites, how much axons change is unknown. We have used advances in axon labeling by viruses and in vivo two-photon microscopy to investigate axon branching and bouton dynamics in primary visual cortex (V1) of adult Macaque monkeys. A nonreplicative adeno-associated virus bearing the gene for enhanced green fluorescent protein (AAV.EGFP) provided persistent labeling of axons, and a custom-designed two-photon microscope enabled repeated imaging of the intact brain over several weeks. We found that large-scale branching patterns were stable but that a subset of small branches associated with terminaux boutons, as well as a subset of en passant boutons, appeared and disappeared every week. Bouton losses and gains were both approximately 7\% of the total population per week, with no net change in the overall density. These results suggest ongoing processes of synaptogenesis and elimination in adult V1.}, address = {The Rockefeller University, New York, New York, USA.}, author = {Stettler, D. D. and Yamahachi, H. and Li, W. and Denk, W. and Gilbert, C. D.}, citeulike-article-id = {3317379}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuron.2006.02.018}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16543135}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16543135}, day = {16}, doi = {10.1016/j.neuron.2006.02.018}, issn = {0896-6273}, journal = {Neuron}, keywords = {axons, remodelling}, month = {March}, number = {6}, pages = {877--887}, posted-at = {2008-09-22 19:34:23}, priority = {3}, title = {Axons and synaptic boutons are highly dynamic in adult visual cortex.}, url = {http://dx.doi.org/10.1016/j.neuron.2006.02.018}, volume = {49}, year = {2006} }

TY - JOUR ID - citeulike:3317379 L3 - citeulike-article-id:3317379 N2 - While recent studies of synaptic stability in adult cerebral cortex have focused on dendrites, how much axons change is unknown. We have used advances in axon labeling by viruses and in vivo two-photon microscopy to investigate axon branching and bouton dynamics in primary visual cortex (V1) of adult Macaque monkeys. A nonreplicative adeno-associated virus bearing the gene for enhanced green fluorescent protein (AAV.EGFP) provided persistent labeling of axons, and a custom-designed two-photon microscope enabled repeated imaging of the intact brain over several weeks. We found that large-scale branching patterns were stable but that a subset of small branches associated with terminaux boutons, as well as a subset of en passant boutons, appeared and disappeared every week. Bouton losses and gains were both approximately 7% of the total population per week, with no net change in the overall density. These results suggest ongoing processes of synaptogenesis and elimination in adult V1. IS - 6 JF - Neuron SN - 0896-6273 AD - The Rockefeller University, New York, New York, USA. EP - 887 TI - Axons and synaptic boutons are highly dynamic in adult visual cortex. VL - 49 SP - 877 KW - axons KW - remodelling AU - Stettler, DD AU - Yamahachi, H AU - Li, W AU - Denk, W AU - Gilbert, CD PY - 2006/03/16/ UR - http://dx.doi.org/10.1016/j.neuron.2006.02.018 ER -