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A method for recording single-cell activity in the frontal-pole cortex of macaque monkeys Export

Journal of Neuroscience Methods, Vol. 177, No. 1. (15 February 2009), pp. 60-66.

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Neurophysiological research has explored most of the prefrontal cortex of macaque monkeys, but the relatively inaccessible frontal-pole cortex remains unexamined. Here we describe a method for gaining access to the frontal-pole cortex with moveable microelectrodes. The key innovation is a direct approach through the frontal air sinus. In addition, the small size of the frontal-pole cortex in macaques led to the design of a smaller recording chamber than typically used in behavioral neurophysiology. The method has proven successful in two subjects, with no adverse health consequences.


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