Exploring genetic interactions and networks with yeast. Export

@article{citeulike:1307466, abstract = {The development and application of genetic tools and resources has enabled a partial genetic-interaction network for the yeast Saccharomyces cerevisiae to be compiled. Analysis of the network, which is ongoing, has already provided a clear picture of the nature and scale of the genetic interactions that robustly sustain biological systems, and how cellular buffering is achieved at the molecular level. Recent studies in yeast have begun to define general principles of genetic networks, and also pave the way for similar studies in metazoan model systems. A comparative understanding of genetic-interaction networks promises insights into some long-standing genetic problems, such as the nature of quantitative traits and the basis of complex inherited disease.}, author = {Boone, Charles and Bussey, Howard and Andrews, Brenda J.}, citeulike-article-id = {1307466}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2085}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2085}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17510664}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17510664}, doi = {10.1038/nrg2085}, issn = {1471-0056}, journal = {Nature reviews. Genetics}, keywords = {evo-devo, genome}, month = {June}, number = {6}, pages = {437--449}, posted-at = {2008-12-31 15:51:23}, priority = {2}, publisher = {Nature Publishing Group}, title = {Exploring genetic interactions and networks with yeast.}, url = {http://dx.doi.org/10.1038/nrg2085}, volume = {8}, year = {2007} }

TY - JOUR ID - citeulike:1307466 L3 - citeulike-article-id:1307466 N2 - The development and application of genetic tools and resources has enabled a partial genetic-interaction network for the yeast Saccharomyces cerevisiae to be compiled. Analysis of the network, which is ongoing, has already provided a clear picture of the nature and scale of the genetic interactions that robustly sustain biological systems, and how cellular buffering is achieved at the molecular level. Recent studies in yeast have begun to define general principles of genetic networks, and also pave the way for similar studies in metazoan model systems. A comparative understanding of genetic-interaction networks promises insights into some long-standing genetic problems, such as the nature of quantitative traits and the basis of complex inherited disease. IS - 6 JF - Nature reviews. Genetics SN - 1471-0056 EP - 449 TI - Exploring genetic interactions and networks with yeast. PB - Nature Publishing Group VL - 8 SP - 437 KW - evo-devo KW - genome AU - Boone, Charles AU - Bussey, Howard AU - Andrews, Brenda PY - 2007/06// UR - http://dx.doi.org/10.1038/nrg2085 ER -