Nucleosome destabilization in the epigenetic regulation of gene expression Export

@article{citeulike:2087646, abstract = {Assembly, mobilization and disassembly of nucleosomes can influence the regulation of gene expression and other processes that act on eukaryotic DNA. Distinct nucleosome-assembly pathways deposit dimeric subunits behind the replication fork or at sites of active processes that mobilize pre-existing nucleosomes. Replication-coupled nucleosome assembly appears to be the default process that maintains silent chromatin, counteracted by active processes that destabilize nucleosomes. Nucleosome stability is regulated by the combined effects of nucleosome-positioning sequences, histone chaperones, ATP-dependent nucleosome remodellers, post-translational modifications and histone variants. Recent studies suggest that histone turnover helps to maintain continuous access to sequence-specific DNA-binding proteins that regulate epigenetic inheritance, providing a dynamic alternative to histone-marking models for the propagation of active chromatin.}, address = {Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA. steveh@fhcrc.org.}, author = {Henikoff, Steven}, citeulike-article-id = {2087646}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2206}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2206}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18059368}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18059368}, day = {4}, doi = {10.1038/nrg2206}, issn = {1471-0064}, journal = {Nat Rev Genet}, keywords = {dynamics, histones}, month = {January}, number = {1}, pages = {15--26}, posted-at = {2008-12-06 17:16:53}, priority = {2}, publisher = {Nature Publishing Group}, title = {Nucleosome destabilization in the epigenetic regulation of gene expression}, url = {http://dx.doi.org/10.1038/nrg2206}, volume = {9}, year = {2008} }

TY - JOUR ID - citeulike:2087646 L3 - citeulike-article-id:2087646 N2 - Assembly, mobilization and disassembly of nucleosomes can influence the regulation of gene expression and other processes that act on eukaryotic DNA. Distinct nucleosome-assembly pathways deposit dimeric subunits behind the replication fork or at sites of active processes that mobilize pre-existing nucleosomes. Replication-coupled nucleosome assembly appears to be the default process that maintains silent chromatin, counteracted by active processes that destabilize nucleosomes. Nucleosome stability is regulated by the combined effects of nucleosome-positioning sequences, histone chaperones, ATP-dependent nucleosome remodellers, post-translational modifications and histone variants. Recent studies suggest that histone turnover helps to maintain continuous access to sequence-specific DNA-binding proteins that regulate epigenetic inheritance, providing a dynamic alternative to histone-marking models for the propagation of active chromatin. IS - 1 JF - Nat Rev Genet SN - 1471-0064 AD - Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA. steveh@fhcrc.org. EP - 26 TI - Nucleosome destabilization in the epigenetic regulation of gene expression PB - Nature Publishing Group VL - 9 SP - 15 KW - dynamics KW - histones AU - Henikoff, Steven PY - 2008/01/04/ UR - http://dx.doi.org/10.1038/nrg2206 ER -