Mechanisms of epigenetic inheritance. Export

@article{citeulike:2821981, abstract = {The mechanisms by which stable gene expression patterns are inherited during cell division are not well understood. Chromatin is subject to a number of covalent modifications and it is generally believed that the transfer of these modifications between cell generations plays a critical role in inheritance, though how this occurs is a matter of debate. In one proposed model, replication of chromatin in a semi-conservative fashion would allow 'template reading' and 'writing' mechanisms to copy modifications from old histones to new histones. Conversely, if chromatin is replicated in a conservative fashion, then other mechanisms, such as the replacement and/or modification of histones during transcription, may mediate the replication of these modifications. Finally, several recent studies suggest that the faithful replication of DNA methylation patterns may be used to propagate histone modifications associated with gene silencing.}, address = {Howard Hughes Medical Institute, Department of Biochemistry \& Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599-7295, USA.}, author = {Martin, C. and Zhang, Y.}, citeulike-article-id = {2821981}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.ceb.2007.04.002}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0955067407000543}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17466502}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17466502}, doi = {10.1016/j.ceb.2007.04.002}, issn = {0955-0674}, journal = {Current opinion in cell biology}, keywords = {genome, histones, replication}, month = {June}, number = {3}, pages = {266--272}, posted-at = {2008-12-09 10:47:18}, priority = {2}, title = {Mechanisms of epigenetic inheritance.}, url = {http://dx.doi.org/10.1016/j.ceb.2007.04.002}, volume = {19}, year = {2007} }

TY - JOUR ID - citeulike:2821981 L3 - citeulike-article-id:2821981 N2 - The mechanisms by which stable gene expression patterns are inherited during cell division are not well understood. Chromatin is subject to a number of covalent modifications and it is generally believed that the transfer of these modifications between cell generations plays a critical role in inheritance, though how this occurs is a matter of debate. In one proposed model, replication of chromatin in a semi-conservative fashion would allow 'template reading' and 'writing' mechanisms to copy modifications from old histones to new histones. Conversely, if chromatin is replicated in a conservative fashion, then other mechanisms, such as the replacement and/or modification of histones during transcription, may mediate the replication of these modifications. Finally, several recent studies suggest that the faithful replication of DNA methylation patterns may be used to propagate histone modifications associated with gene silencing. IS - 3 JF - Current opinion in cell biology SN - 0955-0674 AD - Howard Hughes Medical Institute, Department of Biochemistry & Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599-7295, USA. EP - 272 TI - Mechanisms of epigenetic inheritance. VL - 19 SP - 266 KW - genome KW - histones KW - replication AU - Martin, C AU - Zhang, Y PY - 2007/06// UR - http://dx.doi.org/10.1016/j.ceb.2007.04.002 ER -