Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE Export

@article{citeulike:1235242, abstract = {Increased concentrations of DNA-containing immune complexes in the serum are associated with systemic autoimmune diseases such as lupus. Stimulation of Toll-like receptor 9 (TLR9) by DNA is important in the activation of plasmacytoid dendritic cells and B cells. Here we show that HMGB1, a nuclear DNA-binding protein released from necrotic cells, was an essential component of DNA-containing immune complexes that stimulated cytokine production through a TLR9–MyD88 pathway involving the multivalent receptor RAGE. Moreover, binding of HMGB1 to class A CpG oligodeoxynucleotides considerably augmented cytokine production by means of TLR9 and RAGE. Our data demonstrate a mechanism by which HMGB1 and RAGE activate plasmacytoid dendritic cells and B cells in response to DNA and contribute to autoimmune pathogenesis.}, author = {Tian, Jane and Avalos, Ana M. and Mao, Su-Yau and Chen, Bo and Senthil, Kannaki and Wu, Herren and Parroche, Peggy and Drabic, Stacey and Golenbock, Douglas and Sirois, Cherilyn and Hua, Jing and An, Ling L. and Audoly, Laurent and La Rosa, Greg and Bierhaus, Angelika and Naworth, Peter and Marshak-Rothstein, Ann and Crow, Mary K. and Fitzgerald, Katherine A. and Latz, Eicke and Kiener, Peter A. and Coyle, Anthony J.}, citeulike-article-id = {1235242}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ni1457}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ni1457}, day = {08}, doi = {10.1038/ni1457}, issn = {1529-2908}, journal = {Nature Immunology}, keywords = {dna, hmgb1, rage, tlr9}, month = {April}, number = {5}, pages = {487--496}, posted-at = {2008-07-29 05:08:11}, priority = {3}, publisher = {Nature Publishing Group}, title = {Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE}, url = {http://dx.doi.org/10.1038/ni1457}, volume = {8}, year = {2007} }

TY - JOUR ID - citeulike:1235242 L3 - citeulike-article-id:1235242 N2 - Increased concentrations of DNA-containing immune complexes in the serum are associated with systemic autoimmune diseases such as lupus. Stimulation of Toll-like receptor 9 (TLR9) by DNA is important in the activation of plasmacytoid dendritic cells and B cells. Here we show that HMGB1, a nuclear DNA-binding protein released from necrotic cells, was an essential component of DNA-containing immune complexes that stimulated cytokine production through a TLR9–MyD88 pathway involving the multivalent receptor RAGE. Moreover, binding of HMGB1 to class A CpG oligodeoxynucleotides considerably augmented cytokine production by means of TLR9 and RAGE. Our data demonstrate a mechanism by which HMGB1 and RAGE activate plasmacytoid dendritic cells and B cells in response to DNA and contribute to autoimmune pathogenesis. IS - 5 JF - Nature Immunology SN - 1529-2908 EP - 496 TI - Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE PB - Nature Publishing Group VL - 8 SP - 487 KW - dna KW - hmgb1 KW - rage KW - tlr9 AU - Tian, Jane AU - Avalos, Ana AU - Mao, Su-Yau AU - Chen, Bo AU - Senthil, Kannaki AU - Wu, Herren AU - Parroche, Peggy AU - Drabic, Stacey AU - Golenbock, Douglas AU - Sirois, Cherilyn AU - Hua, Jing AU - An, Ling AU - Audoly, Laurent AU - La Rosa, Greg AU - Bierhaus, Angelika AU - Naworth, Peter AU - Marshak-Rothstein, Ann AU - Crow, Mary AU - Fitzgerald, Katherine AU - Latz, Eicke AU - Kiener, Peter AU - Coyle, Anthony PY - 2007/04/08/ UR - http://dx.doi.org/10.1038/ni1457 ER -