Immune mechanisms in murine gammaherpesvirus-68 infection. Export

@article{citeulike:2456718, abstract = {The murine gamma-herpesvirus-68 (MHV-68) is a relative of the Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) that infects mice. All these gamma-herpesviruses are subject to immune control, but limit the impact of this control through immune evasion. Molecular evasion mechanisms have been described in abundance. However, we can only speculate what EBV and KSHV immune evasion contributes to the viral lifecycle. With MHV-68, we can analyze in vivo the contribution of immunological and virological gene expression to pathogenesis. While the physiology of infection seems quite well conserved between these viruses, the pathologies associated with immune suppression are obviously very different. MHV-68 is therefore more suited to uncovering the basic biology of gamma-herpesvirus infection than to testing disease interventions. Nevertheless, it may make some useful predictions about effective strategies of vaccination and infection control. This review aims to outline our current state of knowledge and to highlight some limitations of the MHV-68 model as it stands, in the hope of stimulating constructive progress.}, address = {Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK. ps233@cam.ac.uk}, author = {Stevenson, P. G. and Efstathiou, S.}, citeulike-article-id = {2456718}, citeulike-linkout-0 = {http://dx.doi.org/10.1089/vim.2005.18.445}, citeulike-linkout-1 = {http://www.liebertonline.com/doi/abs/10.1089/vim.2005.18.445}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16212523}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16212523}, doi = {10.1089/vim.2005.18.445}, issn = {0882-8245}, journal = {Viral Immunol}, keywords = {acute, b\_cells, cd4\_t\_cells, cd8\_t\_cells, immune\_evasion, immune\_response, latency, lytic, mhv68, review, vaccination}, number = {3}, pages = {445--456}, posted-at = {2008-07-29 00:05:51}, priority = {0}, title = {Immune mechanisms in murine gammaherpesvirus-68 infection.}, url = {http://dx.doi.org/10.1089/vim.2005.18.445}, volume = {18}, year = {2005} }

TY - JOUR ID - citeulike:2456718 L3 - citeulike-article-id:2456718 N2 - The murine gamma-herpesvirus-68 (MHV-68) is a relative of the Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) that infects mice. All these gamma-herpesviruses are subject to immune control, but limit the impact of this control through immune evasion. Molecular evasion mechanisms have been described in abundance. However, we can only speculate what EBV and KSHV immune evasion contributes to the viral lifecycle. With MHV-68, we can analyze in vivo the contribution of immunological and virological gene expression to pathogenesis. While the physiology of infection seems quite well conserved between these viruses, the pathologies associated with immune suppression are obviously very different. MHV-68 is therefore more suited to uncovering the basic biology of gamma-herpesvirus infection than to testing disease interventions. Nevertheless, it may make some useful predictions about effective strategies of vaccination and infection control. This review aims to outline our current state of knowledge and to highlight some limitations of the MHV-68 model as it stands, in the hope of stimulating constructive progress. IS - 3 JF - Viral Immunol SN - 0882-8245 AD - Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK. ps233@cam.ac.uk EP - 456 TI - Immune mechanisms in murine gammaherpesvirus-68 infection. VL - 18 SP - 445 KW - acute KW - b_cells KW - cd4_t_cells KW - cd8_t_cells KW - immune_evasion KW - immune_response KW - latency KW - lytic KW - mhv68 KW - review KW - vaccination AU - Stevenson, PG AU - Efstathiou, S PY - 2005/// UR - http://dx.doi.org/10.1089/vim.2005.18.445 ER -