Cell type-specific involvement of RIG-I in antiviral response. Export

@article{citeulike:2886932, abstract = {Toll-like receptors (TLRs) play an important role in antiviral response by recognizing viral components. Recently, a RNA helicase, RIG-I, was also suggested to recognize viral double-stranded RNA. However, how these molecules contribute to viral recognition in vivo is poorly understood. We show by gene targeting that RIG-I is essential for induction of type I interferons (IFNs) after infection with RNA viruses in fibroblasts and conventional dendritic cells (DCs). RIG-I induces type I IFNs by activating IRF3 via IkappaB kinase-related kinases. In contrast, plasmacytoid DCs, which produce large amounts of IFN-alpha, use the TLR system rather than RIG-I for viral detection. Taken together, RIG-I and the TLR system exert antiviral responses in a cell type-specific manner.}, address = {Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.}, author = {Kato, H. and Sato, S. and Yoneyama, M. and Yamamoto, M. and Uematsu, S. and Matsui, K. and Tsujimura, T. and Takeda, K. and Fujita, T. and Takeuchi, O. and Akira, S.}, citeulike-article-id = {2886932}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.immuni.2005.04.010}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16039576}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16039576}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6WSP-4GR2XJ3-5/2/292f88bd7e962769b6d003116d0b5b46}, doi = {10.1016/j.immuni.2005.04.010}, issn = {1074-7613}, journal = {Immunity}, keywords = {dc, innate\_immunity}, month = {July}, number = {1}, pages = {19--28}, posted-at = {2008-08-12 22:39:50}, priority = {3}, title = {Cell type-specific involvement of RIG-I in antiviral response.}, url = {http://dx.doi.org/10.1016/j.immuni.2005.04.010}, volume = {23}, year = {2005} }

TY - JOUR ID - citeulike:2886932 L3 - citeulike-article-id:2886932 N2 - Toll-like receptors (TLRs) play an important role in antiviral response by recognizing viral components. Recently, a RNA helicase, RIG-I, was also suggested to recognize viral double-stranded RNA. However, how these molecules contribute to viral recognition in vivo is poorly understood. We show by gene targeting that RIG-I is essential for induction of type I interferons (IFNs) after infection with RNA viruses in fibroblasts and conventional dendritic cells (DCs). RIG-I induces type I IFNs by activating IRF3 via IkappaB kinase-related kinases. In contrast, plasmacytoid DCs, which produce large amounts of IFN-alpha, use the TLR system rather than RIG-I for viral detection. Taken together, RIG-I and the TLR system exert antiviral responses in a cell type-specific manner. IS - 1 JF - Immunity SN - 1074-7613 AD - Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan. EP - 28 TI - Cell type-specific involvement of RIG-I in antiviral response. VL - 23 SP - 19 KW - dc KW - innate_immunity AU - Kato, H AU - Sato, S AU - Yoneyama, M AU - Yamamoto, M AU - Uematsu, S AU - Matsui, K AU - Tsujimura, T AU - Takeda, K AU - Fujita, T AU - Takeuchi, O AU - Akira, S PY - 2005/07// UR - http://dx.doi.org/10.1016/j.immuni.2005.04.010 ER -