Immune evasion by gamma-herpesviruses Export

@article{citeulike:3054872, abstract = {Persistent viruses, such as herpesviruses, transmit infection by evading cytotoxic T cells during lytic replication. The gamma-herpesviruses additionally evade T cells during the proliferation of latently infected lymphocytes to establish a persistent viral reservoir. Lytic gene expression in sites of lymphoproliferation appears to make a vital contribution to this latent immune evasion. Lytic antigens may therefore be a key immune target. Investigations into a murine gamma-herpesvirus have now provided evidence that vaccination with apathogenic, latency-deficient mutants can largely protect against subsequent wild-type gamma-herpesvirus latency establishment.}, author = {Stevenson, Philip G.}, citeulike-article-id = {3054872}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.coi.2004.05.002}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6VS1-4CK81VP-1/1/e66338988979a6b6f7a8bc76add808dc}, doi = {10.1016/j.coi.2004.05.002}, journal = {Current Opinion in Immunology}, keywords = {cd4\_t\_cells, cd8\_t\_cells, immune\_evasion, mhv68, mk3, review}, month = {August}, number = {4}, pages = {456--462}, posted-at = {2008-07-28 23:53:05}, priority = {0}, title = {Immune evasion by gamma-herpesviruses}, url = {http://dx.doi.org/10.1016/j.coi.2004.05.002}, volume = {16}, year = {2004} }

TY - JOUR ID - citeulike:3054872 L3 - citeulike-article-id:3054872 N2 - Persistent viruses, such as herpesviruses, transmit infection by evading cytotoxic T cells during lytic replication. The gamma-herpesviruses additionally evade T cells during the proliferation of latently infected lymphocytes to establish a persistent viral reservoir. Lytic gene expression in sites of lymphoproliferation appears to make a vital contribution to this latent immune evasion. Lytic antigens may therefore be a key immune target. Investigations into a murine gamma-herpesvirus have now provided evidence that vaccination with apathogenic, latency-deficient mutants can largely protect against subsequent wild-type gamma-herpesvirus latency establishment. IS - 4 JF - Current Opinion in Immunology EP - 462 TI - Immune evasion by gamma-herpesviruses VL - 16 SP - 456 KW - cd4_t_cells KW - cd8_t_cells KW - immune_evasion KW - mhv68 KW - mk3 KW - review AU - Stevenson, Philip PY - 2004/08// UR - http://dx.doi.org/10.1016/j.coi.2004.05.002 ER -