Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology Export

@article{citeulike:3058017, abstract = {We show here that mouse interferon- (IFN-)−producing cells (mIPCs) are a unique subset of immature antigen-presenting cells (APCs) that secrete IFN- upon stimulation with viruses. mIPCs have a plasmacytoid morphology, can be stained with an antibody to Ly6G and Ly6C (anti-Ly6G/C) and are Ly6C+B220+CD11cloCD4+; unlike other dendritic cell subsets, however, they do not express CD8 or CD11b. Although mIPCs undergo apoptosis in vitro, stimulation with viruses, IFN- or CpG oligonucleotides enhanced their survival and T cell stimulatory activity. In vivo, mIPCs were the main producers of IFN-in cytomegalovirus-infected mice, as depletion of Ly6G+/C+ cells abrogated IFN- production. mIPCs produced interleukin 12 (IL-12) in response to viruses and CpG oligodeoxynucleotides, but not bacterial products. Although different pathogens can selectively engage various APC subsets for IL-12 production, IFN- production is restricted to mIPCs' response to viral infection.}, author = {Asselin-Paturel, Carine and Boonstra, Andre and Dalod, Marc and Durand, Isabelle and Yessaad, Nadia and Dezutter-Dambuyant, Colette and Vicari, Alain and O'Garra, Anne and Biron, Christine and Briere, Francine and Trinchieri, Giorgio}, citeulike-article-id = {3058017}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ni736}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ni736}, doi = {10.1038/ni736}, journal = {Nat Immunol}, keywords = {dc, plasmacytoid, type\_1\_ifn}, month = {December}, number = {12}, pages = {1144--1150}, posted-at = {2008-07-30 01:35:08}, priority = {2}, title = {Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology}, url = {http://dx.doi.org/10.1038/ni736}, volume = {2}, year = {2001} }

TY - JOUR ID - citeulike:3058017 L3 - citeulike-article-id:3058017 N2 - We show here that mouse interferon- (IFN-)−producing cells (mIPCs) are a unique subset of immature antigen-presenting cells (APCs) that secrete IFN- upon stimulation with viruses. mIPCs have a plasmacytoid morphology, can be stained with an antibody to Ly6G and Ly6C (anti-Ly6G/C) and are Ly6C+B220+CD11cloCD4+; unlike other dendritic cell subsets, however, they do not express CD8 or CD11b. Although mIPCs undergo apoptosis in vitro, stimulation with viruses, IFN- or CpG oligonucleotides enhanced their survival and T cell stimulatory activity. In vivo, mIPCs were the main producers of IFN-in cytomegalovirus-infected mice, as depletion of Ly6G+/C+ cells abrogated IFN- production. mIPCs produced interleukin 12 (IL-12) in response to viruses and CpG oligodeoxynucleotides, but not bacterial products. Although different pathogens can selectively engage various APC subsets for IL-12 production, IFN- production is restricted to mIPCs' response to viral infection. IS - 12 JF - Nat Immunol EP - 1150 TI - Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology VL - 2 SP - 1144 KW - dc KW - plasmacytoid KW - type_1_ifn AU - Asselin-Paturel, Carine AU - Boonstra, Andre AU - Dalod, Marc AU - Durand, Isabelle AU - Yessaad, Nadia AU - Dezutter-Dambuyant, Colette AU - Vicari, Alain AU - O'Garra, Anne AU - Biron, Christine AU - Briere, Francine AU - Trinchieri, Giorgio PY - 2001/12// UR - http://dx.doi.org/10.1038/ni736 ER -