Germinal-Center Organization and Cellular Dynamics Export

@article{citeulike:3058019, abstract = {Germinal centers (GCs) are important sites of antibody affinity maturation. In the classical model, the GC dark zone contains large centroblasts that are rapidly proliferating and undergoing somatic hypermutation of their antibody variable-region genes. Centroblasts give rise to smaller nonproliferating centrocytes in the light zone that compete for binding antigen on follicular dendritic cells. Recently, the approach of real-time imaging of GCs by two-photon microscopy of intact lymph nodes has provided new insights into GC dynamics that both support and challenge fundamental aspects of this model. Here we review recent and older findings on cell migration, proliferation, and interaction dynamics in the GC and discuss a model in which dark- and light-zone cells are morphologically similar, proliferation occurs in both zones, and GC B cells compete for T cell help as well as antigen.}, author = {Allen, Christopher D. and Okada, Takaharu and Cyster, Jason G.}, citeulike-article-id = {3058019}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.immuni.2007.07.009}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1074761307003706}, citeulike-linkout-2 = {http://www.sciencedirect.com/science/article/B6WSP-4PGR3D5-7/1/2f54ecc659ba44bc9ea4d6c775971bee}, day = {24}, doi = {10.1016/j.immuni.2007.07.009}, journal = {Immunity}, keywords = {b\_cells, germinal\_center, review}, month = {August}, number = {2}, pages = {190--202}, posted-at = {2008-07-30 01:38:23}, priority = {3}, title = {Germinal-Center Organization and Cellular Dynamics}, url = {http://dx.doi.org/10.1016/j.immuni.2007.07.009}, volume = {27}, year = {2007} }

TY - JOUR ID - citeulike:3058019 L3 - citeulike-article-id:3058019 N2 - Germinal centers (GCs) are important sites of antibody affinity maturation. In the classical model, the GC dark zone contains large centroblasts that are rapidly proliferating and undergoing somatic hypermutation of their antibody variable-region genes. Centroblasts give rise to smaller nonproliferating centrocytes in the light zone that compete for binding antigen on follicular dendritic cells. Recently, the approach of real-time imaging of GCs by two-photon microscopy of intact lymph nodes has provided new insights into GC dynamics that both support and challenge fundamental aspects of this model. Here we review recent and older findings on cell migration, proliferation, and interaction dynamics in the GC and discuss a model in which dark- and light-zone cells are morphologically similar, proliferation occurs in both zones, and GC B cells compete for T cell help as well as antigen. IS - 2 JF - Immunity EP - 202 TI - Germinal-Center Organization and Cellular Dynamics VL - 27 SP - 190 KW - b_cells KW - germinal_center KW - review AU - Allen, Christopher AU - Okada, Takaharu AU - Cyster, Jason PY - 2007/08/24/ UR - http://dx.doi.org/10.1016/j.immuni.2007.07.009 ER -