DNA methylation and the Epstein-Barr virus Export

@article{citeulike:3067630, abstract = {EBV is a ubiquitous herpesvirus associated with a variety of lymphoid and epithelial tumors. In healthy lymphocytes and in tumors immune surveillance is evaded by suppression of a family of immunodominant viral antigens. Methylation of a viral promoter plays a crucial role in this suppression. Methylation of the viral genome in the latent state over evolutionary time is believed to account for CpG suppression that distinguishes this virus from most other large DNA viruses. Pharmacologic manipulation of methylation may offer an opportunity to unmask viral antigens and expose tumors to immune surveillance.}, author = {Ambinder, Richard F. and Robertson, Keith D. and Tao, Qian}, citeulike-article-id = {3067630}, citeulike-linkout-0 = {http://dx.doi.org/10.1006/scbi.1999.0137}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6WWY-45FJY9W-H/1/4bb9a28f4e6b84f340ced9d4b89a0d39}, doi = {10.1006/scbi.1999.0137}, journal = {Seminars in Cancer Biology}, keywords = {dna, ebv, methylation, review}, month = {October}, number = {5}, pages = {369--375}, posted-at = {2008-07-31 22:14:24}, priority = {2}, title = {DNA methylation and the Epstein-Barr virus}, url = {http://dx.doi.org/10.1006/scbi.1999.0137}, volume = {9}, year = {1999} }

TY - JOUR ID - citeulike:3067630 L3 - citeulike-article-id:3067630 N2 - EBV is a ubiquitous herpesvirus associated with a variety of lymphoid and epithelial tumors. In healthy lymphocytes and in tumors immune surveillance is evaded by suppression of a family of immunodominant viral antigens. Methylation of a viral promoter plays a crucial role in this suppression. Methylation of the viral genome in the latent state over evolutionary time is believed to account for CpG suppression that distinguishes this virus from most other large DNA viruses. Pharmacologic manipulation of methylation may offer an opportunity to unmask viral antigens and expose tumors to immune surveillance. IS - 5 JF - Seminars in Cancer Biology EP - 375 TI - DNA methylation and the Epstein-Barr virus VL - 9 SP - 369 KW - dna KW - ebv KW - methylation KW - review AU - Ambinder, Richard AU - Robertson, Keith AU - Tao, Qian PY - 1999/10// UR - http://dx.doi.org/10.1006/scbi.1999.0137 ER -