IPC: Professional Type 1 Interferon-Producing Cells and Plasmacytoid Dendritic Cell Precursors Export

@article{citeulike:3137971, abstract = {Abstract Type 1 interferon-(alpha, beta, omega)-producing cells (IPCs), also known as plasmacytoid dendritic cell precursors (pDCs), represent 0.2\%-0.8\% of peripheral blood mononuclear cells in both humans and mice. IPCs display plasma cell morphology, selectively express Toll-like receptor (TLR)-7 and TLR9, and are specialized in rapidly secreting massive amounts of type 1 interferon following viral stimulation. IPCs can promote the function of natural killer cells, B cells, T cells, and myeloid DCs through type 1 interferons during an antiviral immune response. At a later stage of viral infection, IPCs differentiate into a unique type of mature dendritic cell, which directly regulates the function of T cells and thus links innate and adaptive immune responses. After more than two decades of effort by researchers, IPCs finally claim their place in the hematopoietic chart as the most important cell type in antiviral innate immunity. Understanding IPC biology holds future promise for developing cures for infectious diseases, cancer, and autoimmune diseases.}, author = {Liu, Yong J.}, citeulike-article-id = {3137971}, citeulike-linkout-0 = {http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.immunol.23.021704.115633}, citeulike-linkout-1 = {http://dx.doi.org/10.1146/annurev.immunol.23.021704.115633}, doi = {10.1146/annurev.immunol.23.021704.115633}, journal = {Annual Review of Immunology}, keywords = {dc, plasmacytoid, review, type\_1\_ifn}, number = {1}, pages = {275--306}, posted-at = {2008-08-19 21:09:44}, priority = {2}, title = {IPC: Professional Type 1 Interferon-Producing Cells and Plasmacytoid Dendritic Cell Precursors}, url = {http://dx.doi.org/10.1146/annurev.immunol.23.021704.115633}, volume = {23}, year = {2005} }

TY - JOUR ID - citeulike:3137971 L3 - citeulike-article-id:3137971 N2 - Abstract Type 1 interferon-(alpha, beta, omega)-producing cells (IPCs), also known as plasmacytoid dendritic cell precursors (pDCs), represent 0.2%-0.8% of peripheral blood mononuclear cells in both humans and mice. IPCs display plasma cell morphology, selectively express Toll-like receptor (TLR)-7 and TLR9, and are specialized in rapidly secreting massive amounts of type 1 interferon following viral stimulation. IPCs can promote the function of natural killer cells, B cells, T cells, and myeloid DCs through type 1 interferons during an antiviral immune response. At a later stage of viral infection, IPCs differentiate into a unique type of mature dendritic cell, which directly regulates the function of T cells and thus links innate and adaptive immune responses. After more than two decades of effort by researchers, IPCs finally claim their place in the hematopoietic chart as the most important cell type in antiviral innate immunity. Understanding IPC biology holds future promise for developing cures for infectious diseases, cancer, and autoimmune diseases. IS - 1 JF - Annual Review of Immunology EP - 306 TI - IPC: Professional Type 1 Interferon-Producing Cells and Plasmacytoid Dendritic Cell Precursors VL - 23 SP - 275 KW - dc KW - plasmacytoid KW - review KW - type_1_ifn AU - Liu, Yong PY - 2005/// UR - http://dx.doi.org/10.1146/annurev.immunol.23.021704.115633 ER -