Characterization of QT interval adaptation to RR interval changes and its use as a risk-stratifier of arrhythmic mortality in amiodarone-treated survivors of acute myocardial infarction Export

@article{citeulike:2272344, abstract = {A new method is proposed to evaluate the dynamics of QT interval adaptation in response to heart rate (HR) changes. The method considers weighted averages of RR intervals (R\~{}R\~{}) preceding each cardiac beat to express RR interval history accounting for the influence on repolarization duration. A global optimization algorithm is used to determine the weight distribution leading to the lowest regression residual when curve fitting the [QT, R\~{}R\~{}] data using a patient- specific regression model. From the optimum weight distribution, a memory lag L/sub 90/ is estimated, expressing the delay in the QT adaptation to HR changes. On average, RR intervals of the past 150 beats (approximately 2.5 min) are required to model the QT response accurately. From a clinical point of view, the interval of the initial tens of seconds to one minute seems to be most important in the majority of cases. A measure of the optimum regression residual (r/sub opt/) has been calculated, discriminating between post-myocardial infarction patients at high and low risk of arrhythmic death while on treatment with amiodarone. A similar discrimination has been achieved with a variable expressing the character of QT lag behind the RR interval dynamics.}, author = {Pueyo, E. and Smetana, P. and Caminal, P. and Bayes and Malik, M. and Laguna, P.}, booktitle = {Biomedical Engineering, IEEE Transactions on}, citeulike-article-id = {2272344}, citeulike-linkout-0 = {http://dx.doi.org/10.1109/TBME.2004.828050}, citeulike-linkout-1 = {http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=1325811}, doi = {10.1109/TBME.2004.828050}, journal = {Biomedical Engineering, IEEE Transactions on}, keywords = {arrhythmia, infarction, qt\_interval, rr\_interval}, number = {9}, pages = {1511--1520}, posted-at = {2008-01-22 08:20:38}, priority = {2}, title = {Characterization of QT interval adaptation to RR interval changes and its use as a risk-stratifier of arrhythmic mortality in amiodarone-treated survivors of acute myocardial infarction}, url = {http://dx.doi.org/10.1109/TBME.2004.828050}, volume = {51}, year = {2004} }

TY - JOUR ID - citeulike:2272344 L3 - citeulike-article-id:2272344 N2 - A new method is proposed to evaluate the dynamics of QT interval adaptation in response to heart rate (HR) changes. The method considers weighted averages of RR intervals (R~R~) preceding each cardiac beat to express RR interval history accounting for the influence on repolarization duration. A global optimization algorithm is used to determine the weight distribution leading to the lowest regression residual when curve fitting the [QT, R~R~] data using a patient- specific regression model. From the optimum weight distribution, a memory lag L/sub 90/ is estimated, expressing the delay in the QT adaptation to HR changes. On average, RR intervals of the past 150 beats (approximately 2.5 min) are required to model the QT response accurately. From a clinical point of view, the interval of the initial tens of seconds to one minute seems to be most important in the majority of cases. A measure of the optimum regression residual (r/sub opt/) has been calculated, discriminating between post-myocardial infarction patients at high and low risk of arrhythmic death while on treatment with amiodarone. A similar discrimination has been achieved with a variable expressing the character of QT lag behind the RR interval dynamics. IS - 9 JF - Biomedical Engineering, IEEE Transactions on EP - 1520 TI - Characterization of QT interval adaptation to RR interval changes and its use as a risk-stratifier of arrhythmic mortality in amiodarone-treated survivors of acute myocardial infarction VL - 51 T2 - Biomedical Engineering, IEEE Transactions on SP - 1511 KW - arrhythmia KW - infarction KW - qt_interval KW - rr_interval AU - Pueyo, E AU - Smetana, P AU - Caminal, P AU - Bayes AU - Malik, M AU - Laguna, P PY - 2004/// UR - http://dx.doi.org/10.1109/TBME.2004.828050 ER -