Short-term heart rate complexity is reduced in patients with type 1 diabetes mellitus. Export

@article{citeulike:2457178, abstract = {OBJECTIVE: The aim of this study was to test whether new heart rate variability (HRV) complexity measures provide diagnostic information regarding early subclinical autonomic dysfunction in diabetes mellitus (DM). METHODS: HRV in DM type 1 patients (n=17, 10f, 7m) aged 12.9-31.5 years (duration of DM 12.4+/-1.2 years) was compared to a control group of 17 healthy matched probands. The length of R-R intervals was measured over 1h using a telemetric ECG system. In addition to linear measures, we assessed HRV complexity measures, including multiscale entropy (MSE), compression entropy and various symbolic dynamic measures (Shannon and Renyi entropies, normalized complexity index (NCI), and pattern classification). RESULTS: HRV magnitude was significantly reduced in patients with DM. Several HRV complexity parameters (MSE at scales 2-4, Renyi entropy, NCI) were also significantly reduced in diabetics. MSE indices and compression entropy did not correlate with linear measures. CONCLUSIONS: The magnitude and complexity of HRV are reduced in young patients with DM, indicating vagal dysfunction. SIGNIFICANCE: The quantification of HRV complexity in combination with its magnitude may provide an improved diagnostic tool for cardiovascular autonomic neuropathy in DM.}, address = {Institute of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia.}, author = {Javorka, Michal and Trunkvalterova, Zuzana and Tonhajzerova, Ingrid and Javorkova, Jana and Javorka, Kamil and Baumert, Mathias}, citeulike-article-id = {2457178}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.clinph.2007.12.017}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18308624}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18308624}, day = {26}, doi = {10.1016/j.clinph.2007.12.017}, issn = {1388-2457}, journal = {Clin Neurophysiol}, keywords = {approximate\_entropy, autonomic\_ns, can, complexity, diabetes, hrv, symbolic\_analysis, vagal, vfc}, month = {February}, posted-at = {2008-03-02 12:36:54}, priority = {2}, title = {Short-term heart rate complexity is reduced in patients with type 1 diabetes mellitus.}, url = {http://dx.doi.org/10.1016/j.clinph.2007.12.017}, year = {2008} }

TY - JOUR ID - citeulike:2457178 L3 - citeulike-article-id:2457178 N2 - OBJECTIVE: The aim of this study was to test whether new heart rate variability (HRV) complexity measures provide diagnostic information regarding early subclinical autonomic dysfunction in diabetes mellitus (DM). METHODS: HRV in DM type 1 patients (n=17, 10f, 7m) aged 12.9-31.5 years (duration of DM 12.4+/-1.2 years) was compared to a control group of 17 healthy matched probands. The length of R-R intervals was measured over 1h using a telemetric ECG system. In addition to linear measures, we assessed HRV complexity measures, including multiscale entropy (MSE), compression entropy and various symbolic dynamic measures (Shannon and Renyi entropies, normalized complexity index (NCI), and pattern classification). RESULTS: HRV magnitude was significantly reduced in patients with DM. Several HRV complexity parameters (MSE at scales 2-4, Renyi entropy, NCI) were also significantly reduced in diabetics. MSE indices and compression entropy did not correlate with linear measures. CONCLUSIONS: The magnitude and complexity of HRV are reduced in young patients with DM, indicating vagal dysfunction. SIGNIFICANCE: The quantification of HRV complexity in combination with its magnitude may provide an improved diagnostic tool for cardiovascular autonomic neuropathy in DM. JF - Clin Neurophysiol SN - 1388-2457 AD - Institute of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia. TI - Short-term heart rate complexity is reduced in patients with type 1 diabetes mellitus. KW - approximate_entropy KW - autonomic_ns KW - can KW - complexity KW - diabetes KW - hrv KW - symbolic_analysis KW - vagal KW - vfc AU - Javorka, Michal AU - Trunkvalterova, Zuzana AU - Tonhajzerova, Ingrid AU - Javorkova, Jana AU - Javorka, Kamil AU - Baumert, Mathias PY - 2008/02/26/ UR - http://dx.doi.org/10.1016/j.clinph.2007.12.017 ER -