Dietary Glycemic Index, Glycemic Load, Fiber, Simple Sugars, and Insulin Resistance: The Inter99 study Export

@article{citeulike:2744297, abstract = {OBJECTIVE--To examine the relationship between daily glycemic index, daily glycemic load, simple sugars, dietary fiber, and the prevalence of a measure of insulin resistance in 30- to 60-year-old nondiabetic Danish men and women. RESEARCH DESIGN AND METHODS--The Inter99 study is a nonpharmacological intervention study. We used baseline data and examined cross-sectional associations between carbohydrate-related dietary factors and an estimate of insulin resistance in 5,675 subjects at 30-60 years. The dietary intake was estimated from a self-administered food frequency questionnaire, and insulin resistance was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR). Multiple regressions were performed with HOMA-IR as the dependent variable and carbohydrate-related factors as explanatory variables. All models were adjusted for age, sex, smoking, physical activity, total energy intake, BMI, and waist circumference. RESULTS--Intake of lactose was positively associated with HOMA-IR (P < 0.0001), whereas daily glycemic load and intake of glucose, fructose, dietary fiber, total carbohydrate, fruit, and vegetables were inversely associated with HOMA-IR (P < 0.05). Intake of dietary fiber explained the associations with daily glycemic load and total carbohydrate and attenuated the association with fruit and vegetables. No significant associations were observed for daily glycemic index or sucrose. CONCLUSIONS--Habitual intake of diets with a high glycemic index and high glycemic load or diets with a high content of total carbohydrate including simple sugars was not associated with the probability of having insulin resistance. Furthermore, intake of dietary fiber was inversely associated with the probability of having insulin resistance. 10.2337/diacare.28.6.1397}, author = {Lau, Cathrine and Faerch, Kristine and Glumer, Charlotte and Tetens, Inge and Pedersen, Oluf and Carstensen, Bendix and Jorgensen, Torben and Borch-Johnsen, Knut}, citeulike-article-id = {2744297}, citeulike-linkout-0 = {http://dx.doi.org/10.2337/diacare.28.6.1397}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15920058}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15920058}, day = {1}, doi = {10.2337/diacare.28.6.1397}, journal = {Diabetes Care}, keywords = {glycemic\_index, glycemic\_load, higea, homa, insulin\_resistance}, month = {June}, number = {6}, pages = {1397--1403}, posted-at = {2008-05-02 08:01:07}, priority = {2}, title = {Dietary Glycemic Index, Glycemic Load, Fiber, Simple Sugars, and Insulin Resistance: The Inter99 study}, url = {http://dx.doi.org/10.2337/diacare.28.6.1397}, volume = {28}, year = {2005} }

TY - JOUR ID - citeulike:2744297 L3 - citeulike-article-id:2744297 N2 - OBJECTIVE--To examine the relationship between daily glycemic index, daily glycemic load, simple sugars, dietary fiber, and the prevalence of a measure of insulin resistance in 30- to 60-year-old nondiabetic Danish men and women. RESEARCH DESIGN AND METHODS--The Inter99 study is a nonpharmacological intervention study. We used baseline data and examined cross-sectional associations between carbohydrate-related dietary factors and an estimate of insulin resistance in 5,675 subjects at 30-60 years. The dietary intake was estimated from a self-administered food frequency questionnaire, and insulin resistance was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR). Multiple regressions were performed with HOMA-IR as the dependent variable and carbohydrate-related factors as explanatory variables. All models were adjusted for age, sex, smoking, physical activity, total energy intake, BMI, and waist circumference. RESULTS--Intake of lactose was positively associated with HOMA-IR (P < 0.0001), whereas daily glycemic load and intake of glucose, fructose, dietary fiber, total carbohydrate, fruit, and vegetables were inversely associated with HOMA-IR (P < 0.05). Intake of dietary fiber explained the associations with daily glycemic load and total carbohydrate and attenuated the association with fruit and vegetables. No significant associations were observed for daily glycemic index or sucrose. CONCLUSIONS--Habitual intake of diets with a high glycemic index and high glycemic load or diets with a high content of total carbohydrate including simple sugars was not associated with the probability of having insulin resistance. Furthermore, intake of dietary fiber was inversely associated with the probability of having insulin resistance. 10.2337/diacare.28.6.1397 IS - 6 JF - Diabetes Care EP - 1403 TI - Dietary Glycemic Index, Glycemic Load, Fiber, Simple Sugars, and Insulin Resistance: The Inter99 study VL - 28 SP - 1397 KW - glycemic_index KW - glycemic_load KW - higea KW - homa KW - insulin_resistance AU - Lau, Cathrine AU - Faerch, Kristine AU - Glumer, Charlotte AU - Tetens, Inge AU - Pedersen, Oluf AU - Carstensen, Bendix AU - Jorgensen, Torben AU - Borch-Johnsen, Knut PY - 2005/06/01/ UR - http://dx.doi.org/10.2337/diacare.28.6.1397 ER -