Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans. Export

@article{citeulike:3798530, abstract = {Glucagon-like peptide-1 (GLP-1), an incretin, which is used to treat diabetes mellitus in humans, inhibited vagal activity and activated nitrergic pathways. In rats, GLP-1 also increased sympathetic activity, heart rate, and blood pressure (BP). However, the effects of GLP-1 on sympathetic activity in humans are unknown. Our aims were to assess the effects of a GLP-1 agonist with or without alpha(2)-adrenergic or -nitrergic blockade on autonomic nervous functions in humans. In this double-blind study, 48 healthy volunteers were randomized to GLP-1-(7-36) amide, the nitric oxide synthase (NOS) inhibitor N(G)-monomethyl-l-arginine acetate (l-NMMA), the alpha(2)-adrenergic antagonist yohimbine, or placebo (i.e., saline), alone or in combination. Hemodynamic parameters, plasma catecholamines, and cardiac sympathetic and parasympathetic modulation were measured by spectral analysis of heart rate. Thereafter, the effects of GLP-1-(7-36) amide on muscle sympathetic nerve activity (MSNA) were assessed by microneurography in seven subjects. GLP-1 increased (P = 0.02) MSNA but did not affect cardiac sympathetic or parasympathetic indices, as assessed by spectral analysis. Yohimbine increased plasma catecholamines and the low-frequency (LF) component of heart rate power spectrum, suggesting increased cardiac sympathetic activity. l-NMMA increased the BP and reduced the heart rate but did not affect the balance between sympathetic and parasympathetic activity. GLP-1 increases skeletal muscle sympathetic nerve activity but does not appear to affect cardiac sympathetic or parasympathetic activity in humans.}, author = {Bharucha, A. E. and Charkoudian, N. and Andrews, C. N. and Camilleri, M. and Sletten, D. and Zinsmeister, A. R. and Low, P. A.}, citeulike-article-id = {3798530}, citeulike-linkout-0 = {http://dx.doi.org/10.1152/ajpregu.00153.2008}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18596108}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18596108}, doi = {10.1152/ajpregu.00153.2008}, issn = {0363-6119}, journal = {American journal of physiology. Regulatory, integrative and comparative physiology}, keywords = {autonomic\_ns, catecholamines, glp-1, hrv, incretins, spectral\_analysis, sympathovagal\_balance, vagal, vfc}, month = {September}, number = {3}, posted-at = {2008-12-16 18:15:42}, priority = {2}, title = {Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans.}, url = {http://dx.doi.org/10.1152/ajpregu.00153.2008}, volume = {295}, year = {2008} }

TY - JOUR ID - citeulike:3798530 L3 - citeulike-article-id:3798530 N2 - Glucagon-like peptide-1 (GLP-1), an incretin, which is used to treat diabetes mellitus in humans, inhibited vagal activity and activated nitrergic pathways. In rats, GLP-1 also increased sympathetic activity, heart rate, and blood pressure (BP). However, the effects of GLP-1 on sympathetic activity in humans are unknown. Our aims were to assess the effects of a GLP-1 agonist with or without alpha(2)-adrenergic or -nitrergic blockade on autonomic nervous functions in humans. In this double-blind study, 48 healthy volunteers were randomized to GLP-1-(7-36) amide, the nitric oxide synthase (NOS) inhibitor N(G)-monomethyl-l-arginine acetate (l-NMMA), the alpha(2)-adrenergic antagonist yohimbine, or placebo (i.e., saline), alone or in combination. Hemodynamic parameters, plasma catecholamines, and cardiac sympathetic and parasympathetic modulation were measured by spectral analysis of heart rate. Thereafter, the effects of GLP-1-(7-36) amide on muscle sympathetic nerve activity (MSNA) were assessed by microneurography in seven subjects. GLP-1 increased (P = 0.02) MSNA but did not affect cardiac sympathetic or parasympathetic indices, as assessed by spectral analysis. Yohimbine increased plasma catecholamines and the low-frequency (LF) component of heart rate power spectrum, suggesting increased cardiac sympathetic activity. l-NMMA increased the BP and reduced the heart rate but did not affect the balance between sympathetic and parasympathetic activity. GLP-1 increases skeletal muscle sympathetic nerve activity but does not appear to affect cardiac sympathetic or parasympathetic activity in humans. IS - 3 JF - American journal of physiology. Regulatory, integrative and comparative physiology SN - 0363-6119 TI - Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans. VL - 295 KW - autonomic_ns KW - catecholamines KW - glp-1 KW - hrv KW - incretins KW - spectral_analysis KW - sympathovagal_balance KW - vagal KW - vfc AU - Bharucha, AE AU - Charkoudian, N AU - Andrews, CN AU - Camilleri, M AU - Sletten, D AU - Zinsmeister, AR AU - Low, PA PY - 2008/09// UR - http://dx.doi.org/10.1152/ajpregu.00153.2008 ER -