Responsiveness of insulin-induced cardiac sympathetic nerve activation associates with blood pressure regulation in diabetics. Export

@article{citeulike:5975058, abstract = {To quantitatively evaluate the effect of insulin on cardiac sympathetic nerve activity (SNA) and analyze clinical factors associated with insulin sensitivity for the regulation of SNA in diabetics, 29 Japanese type 2 diabetics without neuropathy were recruited. A 2-h control study and a 2-h hyperinsulinemic euglycemic glucose clamp study were performed. From the power spectral analysis of R-R intervals on ECG during both studies, two major components, the low-frequency (LF) and the high-frequency component (HF), were obtained. Then \%LF was calculated as LF/(LF +HF), and the ratio of the average \%LF during the last 30 min of the clamp or the control to the average \%LF for the entire time for clamp or control (R-\%LF) was used as a marker of changes in SNA. R-\%LF was significantly higher during the clamp than in the control (1.07 +/- 0.04 vs. 1.03 +/- 0.03, P < 0.05). High responders (individual R-\%LF during clamp > or = mean + 2SD in control) showed a higher basal mean blood pressure (BP) before the clamp (89 +/- 3 vs. 82 +/- 2, P < 0.03) but not a higher glucose infusion rate (GIR) compared with low responders (<mean + 2SD). Furthermore, R-\%LF showed a positive correlation with basal mean BP (P < 0.02) but not with GIR. These data demonstrate that an acute insulin load stimulates cardiac SNA, and insulin sensitivity in the regulation of SNA may be associated with BP regulation independently of peripheral insulin sensitivity.}, author = {Takagi, Miki and Tanaka, Yasushi and Yamasaki, Yoshimitsu and Yamamoto, Masahiko and Hori, Masatsugu and Nakaniwa, Tomiko and Niwa, Masataka and Uchino, Hiroshi and Tamura, Yoshifumi and Nomiyama, Takashi and Watada, Hirotaka and Kawamori, Ryuzo}, citeulike-article-id = {5975058}, citeulike-linkout-0 = {http://dx.doi.org/10.1152/ajpendo.00169.2002}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/12569084}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=12569084}, doi = {10.1152/ajpendo.00169.2002}, issn = {0193-1849}, journal = {American journal of physiology. Endocrinology and metabolism}, keywords = {autonomic\_ns, blood\_pressure\_regulation, diabetes, euglycaemic\_clamp, insulin\_secretion, neuropathy, spectral\_analysis, sympathetic\_nerve\_activity}, month = {May}, number = {5}, posted-at = {2009-10-20 16:51:23}, priority = {2}, title = {Responsiveness of insulin-induced cardiac sympathetic nerve activation associates with blood pressure regulation in diabetics.}, url = {http://dx.doi.org/10.1152/ajpendo.00169.2002}, volume = {284}, year = {2003} }

TY - JOUR ID - citeulike:5975058 L3 - citeulike-article-id:5975058 N2 - To quantitatively evaluate the effect of insulin on cardiac sympathetic nerve activity (SNA) and analyze clinical factors associated with insulin sensitivity for the regulation of SNA in diabetics, 29 Japanese type 2 diabetics without neuropathy were recruited. A 2-h control study and a 2-h hyperinsulinemic euglycemic glucose clamp study were performed. From the power spectral analysis of R-R intervals on ECG during both studies, two major components, the low-frequency (LF) and the high-frequency component (HF), were obtained. Then %LF was calculated as LF/(LF +HF), and the ratio of the average %LF during the last 30 min of the clamp or the control to the average %LF for the entire time for clamp or control (R-%LF) was used as a marker of changes in SNA. R-%LF was significantly higher during the clamp than in the control (1.07 +/- 0.04 vs. 1.03 +/- 0.03, P < 0.05). High responders (individual R-%LF during clamp > or = mean + 2SD in control) showed a higher basal mean blood pressure (BP) before the clamp (89 +/- 3 vs. 82 +/- 2, P < 0.03) but not a higher glucose infusion rate (GIR) compared with low responders (<mean + 2SD). Furthermore, R-%LF showed a positive correlation with basal mean BP (P < 0.02) but not with GIR. These data demonstrate that an acute insulin load stimulates cardiac SNA, and insulin sensitivity in the regulation of SNA may be associated with BP regulation independently of peripheral insulin sensitivity. IS - 5 JF - American journal of physiology. Endocrinology and metabolism SN - 0193-1849 TI - Responsiveness of insulin-induced cardiac sympathetic nerve activation associates with blood pressure regulation in diabetics. VL - 284 KW - autonomic_ns KW - blood_pressure_regulation KW - diabetes KW - euglycaemic_clamp KW - insulin_secretion KW - neuropathy KW - spectral_analysis KW - sympathetic_nerve_activity AU - Takagi, Miki AU - Tanaka, Yasushi AU - Yamasaki, Yoshimitsu AU - Yamamoto, Masahiko AU - Hori, Masatsugu AU - Nakaniwa, Tomiko AU - Niwa, Masataka AU - Uchino, Hiroshi AU - Tamura, Yoshifumi AU - Nomiyama, Takashi AU - Watada, Hirotaka AU - Kawamori, Ryuzo PY - 2003/05// UR - http://dx.doi.org/10.1152/ajpendo.00169.2002 ER -