Regional and strain-specific gene expression mapping in the adult mouse brain Export

@article{citeulike:942309, abstract = {To determine the genetic causes and molecular mechanisms responsible for neurobehavioral differences in mice, we used highly parallel gene expression profiling to detect genes that are differentially expressed between the 129SvEv and C57BL/6 mouse strains at baseline and in response to seizure. In addition, we identified genes that are differentially expressed in specific brain regions. We found that approximately 1\% of expressed genes are differentially expressed between strains in at least one region of the brain and that the gene expression response to seizure is significantly different between the two inbred strains. The results lead to the identification of differences in gene expression that may account for distinct phenotypes in inbred strains and the unique functions of specific brain regions.}, address = {The Salk Institute for Biological Studies, The Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.}, author = {Sandberg, Rickard and Yasuda, Rie and Pankratz, Daniel G. and Carter, Todd A. and Del Rio, Jo A. and Wodicka, Lisa and Mayford, Mark and Lockhart, David J. and Barlow, Carrolee}, citeulike-article-id = {942309}, citeulike-linkout-0 = {http://www.pnas.org/content/97/20/11038.abstract}, citeulike-linkout-1 = {http://www.pnas.org/content/97/20/11038.full.pdf}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/11005875}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=11005875}, day = {26}, issn = {0027-8424}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {cis\_trans}, month = {September}, number = {20}, pages = {11038--11043}, posted-at = {2007-08-02 00:06:10}, priority = {2}, title = {Regional and strain-specific gene expression mapping in the adult mouse brain}, url = {http://www.pnas.org/content/97/20/11038.abstract}, volume = {97}, year = {2000} }

TY - JOUR ID - citeulike:942309 L3 - citeulike-article-id:942309 N2 - To determine the genetic causes and molecular mechanisms responsible for neurobehavioral differences in mice, we used highly parallel gene expression profiling to detect genes that are differentially expressed between the 129SvEv and C57BL/6 mouse strains at baseline and in response to seizure. In addition, we identified genes that are differentially expressed in specific brain regions. We found that approximately 1% of expressed genes are differentially expressed between strains in at least one region of the brain and that the gene expression response to seizure is significantly different between the two inbred strains. The results lead to the identification of differences in gene expression that may account for distinct phenotypes in inbred strains and the unique functions of specific brain regions. IS - 20 JF - Proceedings of the National Academy of Sciences of the United States of America SN - 0027-8424 AD - The Salk Institute for Biological Studies, The Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. EP - 11043 TI - Regional and strain-specific gene expression mapping in the adult mouse brain VL - 97 SP - 11038 KW - cis_trans AU - Sandberg, Rickard AU - Yasuda, Rie AU - Pankratz, Daniel AU - Carter, Todd AU - Del Rio, Jo AU - Wodicka, Lisa AU - Mayford, Mark AU - Lockhart, David AU - Barlow, Carrolee PY - 2000/09/26/ UR - http://www.pnas.org/content/97/20/11038.abstract ER -