Receptor clustering and signal processing in chemotaxis Export

@article{citeulike:1214655, abstract = {Chemotaxis in Escherichia coli is one of the most thoroughly studied model systems for signal transduction. Receptor-kinase complexes, organized in clusters at the cell poles, sense chemoeffector stimuli and transmit signals to flagellar motors by phosphorylation of a diffusible response regulator protein. Despite the apparent simplicity of the signal transduction pathway, the high sensitivity, wide dynamic range and integration of multiple stimuli of this pathway remain unexplained. Recent advances in computer modeling and in quantitative experimental analysis suggest that cooperative protein interactions in receptor clusters play a crucial role in the signal processing during bacterial chemotaxis.}, address = {ZMBH, University of Heidelberg, Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany. v.sourjik@uni-heidelberg.de}, author = {Sourjik, V.}, citeulike-article-id = {1214655}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tim.2004.10.003}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0966842X04002343}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15539117}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15539117}, doi = {10.1016/j.tim.2004.10.003}, issn = {0966842X}, journal = {Trends in Microbiology}, keywords = {chemotaxis}, month = {December}, number = {12}, pages = {569--576}, posted-at = {2009-11-05 11:58:21}, priority = {2}, title = {Receptor clustering and signal processing in chemotaxis}, url = {http://dx.doi.org/10.1016/j.tim.2004.10.003}, volume = {12}, year = {2004} }

TY - JOUR ID - citeulike:1214655 L3 - citeulike-article-id:1214655 N2 - Chemotaxis in Escherichia coli is one of the most thoroughly studied model systems for signal transduction. Receptor-kinase complexes, organized in clusters at the cell poles, sense chemoeffector stimuli and transmit signals to flagellar motors by phosphorylation of a diffusible response regulator protein. Despite the apparent simplicity of the signal transduction pathway, the high sensitivity, wide dynamic range and integration of multiple stimuli of this pathway remain unexplained. Recent advances in computer modeling and in quantitative experimental analysis suggest that cooperative protein interactions in receptor clusters play a crucial role in the signal processing during bacterial chemotaxis. IS - 12 JF - Trends in Microbiology SN - 0966842X AD - ZMBH, University of Heidelberg, Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany. v.sourjik@uni-heidelberg.de EP - 576 TI - Receptor clustering and signal processing in chemotaxis VL - 12 SP - 569 KW - chemotaxis AU - Sourjik, V PY - 2004/12// UR - http://dx.doi.org/10.1016/j.tim.2004.10.003 ER -