A map of the interactome network of the metazoan C. elegans. Export

@article{citeulike:307440, abstract = {To initiate studies on how protein-protein interaction (or "interactome") networks relate to multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans interactome network. Starting with a subset of metazoan-specific proteins, more than 4000 interactions were identified from high-throughput, yeast two-hybrid (HT=Y2H) screens. Independent coaffinity purification assays experimentally validated the overall quality of this Y2H data set. Together with already described Y2H interactions and interologs predicted in silico, the current version of the Worm Interactome (WI5) map contains approximately 5500 interactions. Topological and biological features of this interactome network, as well as its integration with phenome and transcriptome data sets, lead to numerous biological hypotheses.}, address = {Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.}, author = {Li, S. and Armstrong, C. M. and Bertin, N. and Ge, H. and Milstein, S. and Boxem, M. and Vidalain, P. O. and Han, J. D. and Chesneau, A. and Hao, T. and Goldberg, D. S. and Li, N. and Martinez, M. and Rual, J. F. and Lamesch, P. and Xu, L. and Tewari, M. and Wong, S. L. and Zhang, L. V. and Berriz, G. F. and Jacotot, L. and Vaglio, P. and Reboul, J. and Hirozane-Kishikawa, T. and Li, Q. and Gabel, H. W. and Elewa, A. and Baumgartner, B. and Rose, D. J. and Yu, H. and Bosak, S. and Sequerra, R. and Fraser, A. and Mango, S. E. and Saxton, W. M. and Strome, S. and Van Den Heuvel, S. and Piano, F. and Vandenhaute, J. and Sardet, C. and Gerstein, M. and Doucette-Stamm, L. and Gunsalus, K. C. and Harper, J. W. and Cusick, M. E. and Roth, F. P. and Hill, D. E. and Vidal, M.}, citeulike-article-id = {307440}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1091403}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/303/5657/540}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/14704431}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=14704431}, citeulike-linkout-4 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00006332}, day = {23}, doi = {10.1126/science.1091403}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {connectivity, interaction-graphs, interaction-networks, interactions, interactivity, interactome, interactomes, interactomics, interconnectivity, interoperability, modules, protein-protein-interactions, proteomic-spaces, symmetries}, month = {January}, number = {5657}, pages = {540--543}, posted-at = {2009-07-09 13:02:44}, priority = {2}, title = {A map of the interactome network of the metazoan C. elegans.}, url = {http://dx.doi.org/10.1126/science.1091403}, volume = {303}, year = {2004} }

TY - JOUR ID - citeulike:307440 L3 - citeulike-article-id:307440 N2 - To initiate studies on how protein-protein interaction (or "interactome") networks relate to multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans interactome network. Starting with a subset of metazoan-specific proteins, more than 4000 interactions were identified from high-throughput, yeast two-hybrid (HT=Y2H) screens. Independent coaffinity purification assays experimentally validated the overall quality of this Y2H data set. Together with already described Y2H interactions and interologs predicted in silico, the current version of the Worm Interactome (WI5) map contains approximately 5500 interactions. Topological and biological features of this interactome network, as well as its integration with phenome and transcriptome data sets, lead to numerous biological hypotheses. IS - 5657 JF - Science (New York, N.Y.) SN - 1095-9203 AD - Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA. EP - 543 TI - A map of the interactome network of the metazoan C. elegans. VL - 303 SP - 540 KW - connectivity KW - interaction-graphs KW - interaction-networks KW - interactions KW - interactivity KW - interactome KW - interactomes KW - interactomics KW - interconnectivity KW - interoperability KW - modules KW - protein-protein-interactions KW - proteomic-spaces KW - symmetries AU - Li, S AU - Armstrong, CM AU - Bertin, N AU - Ge, H AU - Milstein, S AU - Boxem, M AU - Vidalain, PO AU - Han, JD AU - Chesneau, A AU - Hao, T AU - Goldberg, DS AU - Li, N AU - Martinez, M AU - Rual, JF AU - Lamesch, P AU - Xu, L AU - Tewari, M AU - Wong, SL AU - Zhang, LV AU - Berriz, GF AU - Jacotot, L AU - Vaglio, P AU - Reboul, J AU - Hirozane-Kishikawa, T AU - Li, Q AU - Gabel, HW AU - Elewa, A AU - Baumgartner, B AU - Rose, DJ AU - Yu, H AU - Bosak, S AU - Sequerra, R AU - Fraser, A AU - Mango, SE AU - Saxton, WM AU - Strome, S AU - Van Den Heuvel, S AU - Piano, F AU - Vandenhaute, J AU - Sardet, C AU - Gerstein, M AU - Doucette-Stamm, L AU - Gunsalus, KC AU - Harper, JW AU - Cusick, ME AU - Roth, FP AU - Hill, DE AU - Vidal, M PY - 2004/01/23/ UR - http://dx.doi.org/10.1126/science.1091403 ER -