Origin of Stem Cells in Organogenesis Export

@article{citeulike:3802036, abstract = {The development of individual organs in animal embryos involves the formation of tissue-specific stem cells that sustain cell renewal of their own tissue for the lifetime of the organism. Although details of their origin are not always known, tissue-specific stem cells usually share the expression of key transcription factors with cells of the embryonic rudiment from which they arise, and are probably in a similar developmental state. On the other hand, the isolation of pluripotent stem cells from the postnatal organism has encouraged the formulation of models of embryonic and postnatal development that are at variance with the conventional ones. Possible explanations for the existence of such cells, and the issue of whether they also exist in vivo, are discussed. 10.1126/science.1162782}, author = {Slack, J. M. W.}, citeulike-article-id = {3802036}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1162782}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/322/5907/1498}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19056975}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19056975}, day = {5}, doi = {10.1126/science.1162782}, journal = {Science}, keywords = {biological-structures, blastema, cell-types, developing, differentiation, embryogenesis, formation, organisms, organogenesis, organs, stem-cells, tissues}, month = {December}, number = {5907}, pages = {1498--1501}, posted-at = {2009-06-17 19:27:41}, priority = {2}, title = {Origin of Stem Cells in Organogenesis}, url = {http://dx.doi.org/10.1126/science.1162782}, volume = {322}, year = {2008} }

TY - JOUR ID - citeulike:3802036 L3 - citeulike-article-id:3802036 N2 - The development of individual organs in animal embryos involves the formation of tissue-specific stem cells that sustain cell renewal of their own tissue for the lifetime of the organism. Although details of their origin are not always known, tissue-specific stem cells usually share the expression of key transcription factors with cells of the embryonic rudiment from which they arise, and are probably in a similar developmental state. On the other hand, the isolation of pluripotent stem cells from the postnatal organism has encouraged the formulation of models of embryonic and postnatal development that are at variance with the conventional ones. Possible explanations for the existence of such cells, and the issue of whether they also exist in vivo, are discussed. 10.1126/science.1162782 IS - 5907 JF - Science EP - 1501 TI - Origin of Stem Cells in Organogenesis VL - 322 SP - 1498 KW - biological-structures KW - blastema KW - cell-types KW - developing KW - differentiation KW - embryogenesis KW - formation KW - organisms KW - organogenesis KW - organs KW - stem-cells KW - tissues AU - Slack, JMW PY - 2008/12/05/ UR - http://dx.doi.org/10.1126/science.1162782 ER -