Preclinical Alzheimer disease: neuropsychological test performance 1.5 to 8 years prior to onset. Export

@article{citeulike:4472310, abstract = {OBJECTIVE: To determine if individuals ultimately diagnosed with Alzheimer disease (AD) exhibited evidence of cognitive impairment on neuropsychological tests administered between 1.5 years and 8.1 years before dementia onset. METHODS: A total of 693 community-dwelling individuals, part of the Cardiovascular Health Study, completed a neuropsychological test battery in 1991/92. Subjects were followed annually over the next 8 years (median follow-up = 7.4 years). Seventy-two individuals were ultimately diagnosed with AD (median follow-up = 4.5 years): 24 with AD onset 1.5 to 3.4 years after baseline neuropsychological testing, 20 with AD onset 3.5 to 5.0 years after testing, and 28 with onset 5.1 to 8.1 years after testing. A total of 621 individuals remained nondemented throughout the 8 years of follow-up (median follow-up = 7.5 years). RESULTS: Subjects ultimately diagnosed with AD had poorer scores on baseline neuropsychological measures than subjects who remained nondemented. Although individuals closest to AD onset (i.e., 1.5 to 3.4 years) performed the most poorly, cognitive impairment was detected in individuals who did not develop AD until 5 to 8 years later. CONCLUSIONS: Cognitive changes can be detected well before onset of Alzheimer disease.}, author = {Saxton, J. and Lopez, O. L. and Ratcliff, G. and Dulberg, C. and Fried, L. P. and Carlson, M. C. and Newman, A. B. and Kuller, L.}, citeulike-article-id = {4472310}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/15623697}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=15623697}, day = {28}, issn = {1526-632X}, journal = {Neurology}, keywords = {alzheimer, cerebral-degenerations, diseases, icd, icd-9, nervous-systems, preclinical}, month = {December}, number = {12}, pages = {2341--2347}, posted-at = {2009-05-06 17:19:50}, priority = {2}, title = {Preclinical Alzheimer disease: neuropsychological test performance 1.5 to 8 years prior to onset.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/15623697}, volume = {63}, year = {2004} }

TY - JOUR ID - citeulike:4472310 L3 - citeulike-article-id:4472310 N2 - OBJECTIVE: To determine if individuals ultimately diagnosed with Alzheimer disease (AD) exhibited evidence of cognitive impairment on neuropsychological tests administered between 1.5 years and 8.1 years before dementia onset. METHODS: A total of 693 community-dwelling individuals, part of the Cardiovascular Health Study, completed a neuropsychological test battery in 1991/92. Subjects were followed annually over the next 8 years (median follow-up = 7.4 years). Seventy-two individuals were ultimately diagnosed with AD (median follow-up = 4.5 years): 24 with AD onset 1.5 to 3.4 years after baseline neuropsychological testing, 20 with AD onset 3.5 to 5.0 years after testing, and 28 with onset 5.1 to 8.1 years after testing. A total of 621 individuals remained nondemented throughout the 8 years of follow-up (median follow-up = 7.5 years). RESULTS: Subjects ultimately diagnosed with AD had poorer scores on baseline neuropsychological measures than subjects who remained nondemented. Although individuals closest to AD onset (i.e., 1.5 to 3.4 years) performed the most poorly, cognitive impairment was detected in individuals who did not develop AD until 5 to 8 years later. CONCLUSIONS: Cognitive changes can be detected well before onset of Alzheimer disease. IS - 12 JF - Neurology SN - 1526-632X EP - 2347 TI - Preclinical Alzheimer disease: neuropsychological test performance 1.5 to 8 years prior to onset. VL - 63 SP - 2341 KW - alzheimer KW - cerebral-degenerations KW - diseases KW - icd KW - icd-9 KW - nervous-systems KW - preclinical AU - Saxton, J AU - Lopez, OL AU - Ratcliff, G AU - Dulberg, C AU - Fried, LP AU - Carlson, MC AU - Newman, AB AU - Kuller, L PY - 2004/12/28/ UR - http://view.ncbi.nlm.nih.gov/pubmed/15623697 ER -