Signal Transduction Pathways as Concurrent Reactive Systems: A Modeling and Simulation Approach Using LSCs and the Play-Engine Export

@article{citeulike:4683129, abstract = {Signal transduction pathways describe how cells respond to extracellular signals which are received by receptors at the cell membrane and usually transferred into the nucleus. In this paper we present our approach to model these signal transduction pathways as concurrent reactive systems by means of Life Sequence Charts and to simulate them using the Play-Engine tool. This aspect is part of a bigger approach, where we provide an extendable system to generate models of signal transduction pathways in different modeling languages and to simulate these models with the corresponding simulation tools.}, address = {Amsterdam, The Netherlands, The Netherlands}, author = {T\"{a}ubner, Claudia and Eckstein, Silke}, citeulike-article-id = {4683129}, citeulike-linkout-0 = {http://portal.acm.org/citation.cfm?id=1342631}, citeulike-linkout-1 = {http://dx.doi.org/10.1016/j.entcs.2007.12.011}, doi = {10.1016/j.entcs.2007.12.011}, issn = {1571-0661}, journal = {Electron. Notes Theor. Comput. Sci.}, keywords = {biological-structures, biological-systems, concurrency, organisms, pathways, reactive-systems, reactivity, signal-processing, simulating, transducers}, number = {3}, pages = {149--164}, posted-at = {2009-05-30 22:49:49}, priority = {2}, publisher = {Elsevier Science Publishers B. V.}, title = {Signal Transduction Pathways as Concurrent Reactive Systems: A Modeling and Simulation Approach Using LSCs and the Play-Engine}, url = {http://dx.doi.org/10.1016/j.entcs.2007.12.011}, volume = {194}, year = {2008} }

TY - JOUR ID - citeulike:4683129 L3 - citeulike-article-id:4683129 N2 - Signal transduction pathways describe how cells respond to extracellular signals which are received by receptors at the cell membrane and usually transferred into the nucleus. In this paper we present our approach to model these signal transduction pathways as concurrent reactive systems by means of Life Sequence Charts and to simulate them using the Play-Engine tool. This aspect is part of a bigger approach, where we provide an extendable system to generate models of signal transduction pathways in different modeling languages and to simulate these models with the corresponding simulation tools. IS - 3 JF - Electron. Notes Theor. Comput. Sci. SN - 1571-0661 AD - Amsterdam, The Netherlands, The Netherlands EP - 164 TI - Signal Transduction Pathways as Concurrent Reactive Systems: A Modeling and Simulation Approach Using LSCs and the Play-Engine PB - Elsevier Science Publishers B. V. VL - 194 SP - 149 KW - biological-structures KW - biological-systems KW - concurrency KW - organisms KW - pathways KW - reactive-systems KW - reactivity KW - signal-processing KW - simulating KW - transducers AU - T\"{a}ubner, Claudia AU - Eckstein, Silke PY - 2008/// UR - http://dx.doi.org/10.1016/j.entcs.2007.12.011 ER -