Epigenes: design and construction of new hereditary units Export

@article{citeulike:4770047, abstract = {A plasmid digene construction designed before [Tchuraev, R.N. (1982) J. Gen. Biol. 43, 79–87] has been realised, including feedback by repressing proteins with given trigger regime of gene functioning. Experimental tests of the expected epigene properties of the obtained pECPI recombinant plasmid involving lacI and cI 857 regulatory genes have shown a phenomenon of steady inheritance of two alternative epigenotypes lacI 1 cI 0 and lacI 0 cI 1 , as well as an external toggle switch through metabolitic and temperature signals from one inherited functional state of the cyclic digene system into another. Thus, we have constructed a hereditary unit of a specific kind, namely, a two-component stationary epigene with preset properties.}, author = {Tchuraev, R.}, citeulike-article-id = {4770047}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S0014-5793(00)02300-0}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0014-5793(00)02300-0}, doi = {10.1016/S0014-5793(00)02300-0}, issn = {00145793}, journal = {FEBS Letters}, keywords = {epigenetic}, month = {December}, number = {3}, pages = {200--202}, posted-at = {2009-06-07 21:02:06}, priority = {2}, title = {Epigenes: design and construction of new hereditary units}, url = {http://dx.doi.org/10.1016/S0014-5793(00)02300-0}, volume = {486}, year = {2000} }

TY - JOUR ID - citeulike:4770047 L3 - citeulike-article-id:4770047 N2 - A plasmid digene construction designed before [Tchuraev, R.N. (1982) J. Gen. Biol. 43, 79–87] has been realised, including feedback by repressing proteins with given trigger regime of gene functioning. Experimental tests of the expected epigene properties of the obtained pECPI recombinant plasmid involving lacI and cI 857 regulatory genes have shown a phenomenon of steady inheritance of two alternative epigenotypes lacI 1 cI 0 and lacI 0 cI 1 , as well as an external toggle switch through metabolitic and temperature signals from one inherited functional state of the cyclic digene system into another. Thus, we have constructed a hereditary unit of a specific kind, namely, a two-component stationary epigene with preset properties. IS - 3 JF - FEBS Letters SN - 00145793 EP - 202 TI - Epigenes: design and construction of new hereditary units VL - 486 SP - 200 KW - epigenetic AU - Tchuraev, R PY - 2000/12/15/ UR - http://dx.doi.org/10.1016/S0014-5793(00)02300-0 ER -