Hypoxia Induces Transcription Factor ETS-1 via the Activity of Hypoxia-Inducible Factor-1 Export

@article{citeulike:6070988, abstract = {ETS-1 plays an important role in angiogenesis and cancer invasion, and hypoxia is a common feature in these phenomena. We examined whether hypoxia influenced ETS-1 expression. Hypoxia induced ETS-1 in a human bladder cancer cell line, T24, and promoter analysis revealed that the deletion of −424 to −279 bp from the human ETS-1 promoter decreased the hypoxia-mediated inducibility. This region contained a hypoxia responsive element-like sequence, and HIF-1 bound to it under the hypoxic condition. Double-stranded synthetic oligonucleotides of this sequence as a decoy inhibited the hypoxia-mediated induciblity. These results indicate that hypoxia induces ETS-1 via the activity of HIF-1. }, author = {Oikawa, M.}, citeulike-article-id = {6070988}, citeulike-linkout-0 = {http://dx.doi.org/10.1006/bbrc.2001.5927}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0006-291X(01)95927-3}, day = {23}, doi = {10.1006/bbrc.2001.5927}, issn = {0006291X}, journal = {Biochemical and Biophysical Research Communications}, keywords = {activity, ets-1, factor, factor-1, hypoxia, hypoxia-inducible, induces, of, the, transcription, via}, month = {November}, number = {1}, pages = {39--43}, posted-at = {2009-11-04 18:53:32}, priority = {2}, title = {Hypoxia Induces Transcription Factor ETS-1 via the Activity of Hypoxia-Inducible Factor-1}, url = {http://dx.doi.org/10.1006/bbrc.2001.5927}, volume = {289}, year = {2001} }

TY - JOUR ID - citeulike:6070988 L3 - citeulike-article-id:6070988 N2 - ETS-1 plays an important role in angiogenesis and cancer invasion, and hypoxia is a common feature in these phenomena. We examined whether hypoxia influenced ETS-1 expression. Hypoxia induced ETS-1 in a human bladder cancer cell line, T24, and promoter analysis revealed that the deletion of −424 to −279 bp from the human ETS-1 promoter decreased the hypoxia-mediated inducibility. This region contained a hypoxia responsive element-like sequence, and HIF-1 bound to it under the hypoxic condition. Double-stranded synthetic oligonucleotides of this sequence as a decoy inhibited the hypoxia-mediated induciblity. These results indicate that hypoxia induces ETS-1 via the activity of HIF-1. IS - 1 JF - Biochemical and Biophysical Research Communications SN - 0006291X EP - 43 TI - Hypoxia Induces Transcription Factor ETS-1 via the Activity of Hypoxia-Inducible Factor-1 VL - 289 SP - 39 KW - activity KW - ets-1 KW - factor KW - factor-1 KW - hypoxia KW - hypoxia-inducible KW - induces KW - of KW - the KW - transcription KW - via AU - Oikawa, M PY - 2001/11/23/ UR - http://dx.doi.org/10.1006/bbrc.2001.5927 ER -