Generating specificity and diversity in the transcriptional response to hypoxia. Export

@article{citeulike:6071674, abstract = {The sensing of oxygen levels and maintenance of oxygen homeostasis is crucial for cells. The hypoxic-sensitive regulation of gene expression allows information about the oxygen status to be converted into appropriate cellular responses. Although there is a core transcriptional pathway, the signalling cascade can be modified to allow diversity and specificity in the transcriptional output. In this Review, we discuss recent advances in our understanding of the mechanisms and factors that contribute to the observed diversity and specificity. A deeper knowledge about how hypoxic signalling is tuned will further our understanding of the cellular hypoxic response in normal physiology and how it becomes derailed in disease.}, author = {Lendahl, Urban and Lee, Kian Leong L. and Yang, Henry and Poellinger, Lorenz}, citeulike-article-id = {6071674}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2665}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19884889}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19884889}, day = {3}, doi = {10.1038/nrg2665}, issn = {1471-0064}, journal = {Nature reviews. Genetics}, keywords = {and, diversity, generating, hypoxia, in, response, specificity, the, to, transcriptional}, month = {December}, number = {12}, pages = {821--832}, posted-at = {2009-11-04 22:23:07}, priority = {2}, title = {Generating specificity and diversity in the transcriptional response to hypoxia.}, url = {http://dx.doi.org/10.1038/nrg2665}, volume = {10}, year = {2009} }

TY - JOUR ID - citeulike:6071674 L3 - citeulike-article-id:6071674 N2 - The sensing of oxygen levels and maintenance of oxygen homeostasis is crucial for cells. The hypoxic-sensitive regulation of gene expression allows information about the oxygen status to be converted into appropriate cellular responses. Although there is a core transcriptional pathway, the signalling cascade can be modified to allow diversity and specificity in the transcriptional output. In this Review, we discuss recent advances in our understanding of the mechanisms and factors that contribute to the observed diversity and specificity. A deeper knowledge about how hypoxic signalling is tuned will further our understanding of the cellular hypoxic response in normal physiology and how it becomes derailed in disease. IS - 12 JF - Nature reviews. Genetics SN - 1471-0064 EP - 832 TI - Generating specificity and diversity in the transcriptional response to hypoxia. VL - 10 SP - 821 KW - and KW - diversity KW - generating KW - hypoxia KW - in KW - response KW - specificity KW - the KW - to KW - transcriptional AU - Lendahl, Urban AU - Lee, Kian Leong AU - Yang, Henry AU - Poellinger, Lorenz PY - 2009/12/03/ UR - http://dx.doi.org/10.1038/nrg2665 ER -