Fluoxetine and Sertraline Attenuate Postischemic Brain Injury in Mice. Export

@article{citeulike:6071692, abstract = {This study aimed to investigate whether selective serotonin reuptake inhibitors (SSRIs) attenuate brain injury and facilitate recovery following photothrombotic cortical ischemia in mice. Male ICR mice were anesthetized and systemically administered Rose Bengal. Permanent focal ischemia was induced in the medial frontal and somatosensory cortices by irradiating the skull with cold light laser. The animals were treated with fluoxetine or sertraline once a day for 14 d starting 1 h after ischemic insult. Treatment with fluoxetine and sertraline significantly reduced the infarct size. The Evans blue extravasation indices of the fluoxetine- and sertraline-treated groups were significantly lower than that of the vehicle group. Treatment with fluoxetine and sertraline shifted the lower limit of the mean arterial blood pressure for cerebral blood flow autoregulation toward normal, and significantly increased the expression of heme oxygenase-1 (HO-1) and hypoxia-inducible factor-1alpha (HIF-1alpha) proteins in the ischemic region. These results suggest that SSRIs, such as fluoxetine and sertraline, facilitate recovery following photothrombotic cortical ischemia via enhancement of HO-1 and HIF-1alpha proteins expression, thereby providing a benefit in therapy of cerebral ischemia.}, author = {Shin, Tae Kyeong K. and Kang, Mi Sun S. and Lee, Ho Youn Y. and Seo, Moo Sang S. and Kim, Si Geun G. and Kim, Chi Dae D. and Lee, Won Suk S.}, citeulike-article-id = {6071692}, citeulike-linkout-0 = {http://dx.doi.org/10.4196/kjpp.2009.13.3.257}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19885045}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19885045}, doi = {10.4196/kjpp.2009.13.3.257}, issn = {1226-4512}, journal = {The Korean journal of physiology \& pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology}, keywords = {and, attenuate, brain, fluoxetine, in, injury, mice, postischemic, sertraline}, month = {June}, number = {3}, pages = {257--263}, posted-at = {2009-11-04 22:30:13}, priority = {2}, title = {Fluoxetine and Sertraline Attenuate Postischemic Brain Injury in Mice.}, url = {http://dx.doi.org/10.4196/kjpp.2009.13.3.257}, volume = {13}, year = {2009} }

TY - JOUR ID - citeulike:6071692 L3 - citeulike-article-id:6071692 N2 - This study aimed to investigate whether selective serotonin reuptake inhibitors (SSRIs) attenuate brain injury and facilitate recovery following photothrombotic cortical ischemia in mice. Male ICR mice were anesthetized and systemically administered Rose Bengal. Permanent focal ischemia was induced in the medial frontal and somatosensory cortices by irradiating the skull with cold light laser. The animals were treated with fluoxetine or sertraline once a day for 14 d starting 1 h after ischemic insult. Treatment with fluoxetine and sertraline significantly reduced the infarct size. The Evans blue extravasation indices of the fluoxetine- and sertraline-treated groups were significantly lower than that of the vehicle group. Treatment with fluoxetine and sertraline shifted the lower limit of the mean arterial blood pressure for cerebral blood flow autoregulation toward normal, and significantly increased the expression of heme oxygenase-1 (HO-1) and hypoxia-inducible factor-1alpha (HIF-1alpha) proteins in the ischemic region. These results suggest that SSRIs, such as fluoxetine and sertraline, facilitate recovery following photothrombotic cortical ischemia via enhancement of HO-1 and HIF-1alpha proteins expression, thereby providing a benefit in therapy of cerebral ischemia. IS - 3 JF - The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology SN - 1226-4512 EP - 263 TI - Fluoxetine and Sertraline Attenuate Postischemic Brain Injury in Mice. VL - 13 SP - 257 KW - and KW - attenuate KW - brain KW - fluoxetine KW - in KW - injury KW - mice KW - postischemic KW - sertraline AU - Shin, Tae Kyeong AU - Kang, Mi Sun AU - Lee, Ho Youn AU - Seo, Moo Sang AU - Kim, Si Geun AU - Kim, Chi Dae AU - Lee, Won Suk PY - 2009/06// UR - http://dx.doi.org/10.4196/kjpp.2009.13.3.257 ER -