A radical view of pathological vasculature.
Striking results reported by Okuno et al. (2012) in the July issue of Nature Medicine show that the ataxia telangiectasia mutated (ATM) kinase counteracts excessive oxygen radical production in immature angiogenic blood vessels. Its deletion results in activation of the mitogen-activated protein kinase p38α and arrest of pathological angiogenesis. Copyright © 2012 Elsevier Inc. All rights reserved.