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The Mechanism of Tissue-Restricted Antigen Gene Expression by AIRE.

by: Kristina Zumer, Kalle Saksela, B. Matija Peterlin
Journal of immunology (Baltimore, Md. : 1950), Vol. 190, No. 6. (15 March 2013), pp. 2479-2482, doi:10.4049/jimmunol.1203210  Key: citeulike:12115969

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Abstract

The autoimmune regulator is a critical transcription factor for generating central tolerance in the thymus. Recent studies have revealed how the autoimmune regulator targets many otherwise tissue-restricted Ag genes to enable negative selection of autoreactive T cells.


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