USF1 gene variants contribute to metabolic traits in men in a longitudinal 32-year follow-up study.

@article{citeulike:2190787, abstract = {AIMS/HYPOTHESIS: Genetic variants of upstream transcription factor 1 (USF1) have previously been associated with dyslipidaemias in family studies. Our aim was to further address the role of USF1 in metabolic syndrome and cardiovascular traits at the population level in a large Swedish male cohort (n = 2,322) with multiple measurements for risk factors during 32 years of follow-up. METHODS: Participants, born in 1920-1924, were examined at 50, 60, 70 and 77 years of age. The follow-up period for cardiovascular events was 1970-2002. We genotyped three haplotype tagging polymorphisms capturing the major allelic variants of USF1. RESULTS: SNP rs2774279 was associated with the metabolic syndrome. The minor allele of rs2774279 was less common among individuals with metabolic syndrome than among healthy controls [p = 0.0029 when metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III; p = 0.0073 when defined according to the International Diabetes Federation (IDF)]. The minor allele of rs2774279 was also associated with lower BMI, lower fasting glucose values and higher HDL-cholesterol concentrations in longitudinal analyses. With SNP rs2073658, a borderline association with metabolic syndrome was observed (p = 0.036, IDF), the minor allele being the risk-increasing allele. The minor allele of rs2073658 also associated with higher total and LDL-cholesterol, apolipoprotein B-100 and lipoprotein(a) concentrations in longitudinal analyses. Importantly, these trends with respect to the allelic variants prevailed throughout the follow-up time of three decades. CONCLUSIONS/INTERPRETATION: Our results suggest that USF1 variants associate with the metabolic syndrome at population level and influence the cardiovascular risk factors throughout adulthood in a consistent, longitudinal manner.}, address = {Department of Molecular Medicine, National Public Health Institute, Biomedicum, Haartmaninkatu 8, 00290, Helsinki, Finland.}, author = {Auro, K and Kristiansson, K and Zethelius, B and Berne, C and Lannfelt, L and Taskinen, M-R R. and Jauhiainen, M and Perola, M and Peltonen, L and Syv\"{a}nen, A-C C. }, citeulike-article-id = {2190787}, doi = {10.1007/s00125-007-0892-9}, issn = {0012-186X}, journal = {Diabetologia}, month = {December}, posted-at = {2008-01-03 07:42:44}, priority = {2}, title = {USF1 gene variants contribute to metabolic traits in men in a longitudinal 32-year follow-up study.}, url = {http://dx.doi.org/10.1007/s00125-007-0892-9}, year = {2007} }

TY - JOUR ID - citeulike:2190787 L3 - citeulike-article-id:2190787 TI - USF1 gene variants contribute to metabolic traits in men in a longitudinal 32-year follow-up study. JF - Diabetologia AD - Department of Molecular Medicine, National Public Health Institute, Biomedicum, Haartmaninkatu 8, 00290, Helsinki, Finland. SN - 0012-186X N2 - AIMS/HYPOTHESIS: Genetic variants of upstream transcription factor 1 (USF1) have previously been associated with dyslipidaemias in family studies. Our aim was to further address the role of USF1 in metabolic syndrome and cardiovascular traits at the population level in a large Swedish male cohort (n = 2,322) with multiple measurements for risk factors during 32 years of follow-up. METHODS: Participants, born in 1920-1924, were examined at 50, 60, 70 and 77 years of age. The follow-up period for cardiovascular events was 1970-2002. We genotyped three haplotype tagging polymorphisms capturing the major allelic variants of USF1. RESULTS: SNP rs2774279 was associated with the metabolic syndrome. The minor allele of rs2774279 was less common among individuals with metabolic syndrome than among healthy controls [p = 0.0029 when metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III; p = 0.0073 when defined according to the International Diabetes Federation (IDF)]. The minor allele of rs2774279 was also associated with lower BMI, lower fasting glucose values and higher HDL-cholesterol concentrations in longitudinal analyses. With SNP rs2073658, a borderline association with metabolic syndrome was observed (p = 0.036, IDF), the minor allele being the risk-increasing allele. The minor allele of rs2073658 also associated with higher total and LDL-cholesterol, apolipoprotein B-100 and lipoprotein(a) concentrations in longitudinal analyses. Importantly, these trends with respect to the allelic variants prevailed throughout the follow-up time of three decades. CONCLUSIONS/INTERPRETATION: Our results suggest that USF1 variants associate with the metabolic syndrome at population level and influence the cardiovascular risk factors throughout adulthood in a consistent, longitudinal manner. AU - Auro, K AU - Kristiansson, K AU - Zethelius, B AU - Berne, C AU - Lannfelt, L AU - Taskinen, M-R AU - Jauhiainen, M AU - Perola, M AU - Peltonen, L AU - Syvänen, A-C PY - 2007/12/21/ UR - http://dx.doi.org/10.1007/s00125-007-0892-9 ER -