More than half of the patients with acute Puumala hantavirus infection have abnormal cardiac findings. Export

@article{citeulike:3445866, abstract = {This study was conducted to determine the frequency, severity and outcome of cardiac findings in patients with acute Puumala hantavirus-induced nephropathia epidemica (NE). 70 consecutive, hospital-treated patients with serologically confirmed NE were prospectively examined using serial electrocardiograms (ECG), plasma troponin I, tumour necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), and echocardiography (ECHO). Examinations were repeated after 3 and 12 months. ECG changes were observed in 57\% of patients. Plasma troponin I levels remained normal in all. In six patients, ECHO showed left ventricular contraction abnormalities, and 1 patient had mild pericardial effusion. There were no differences in clinical or standard laboratory findings or in plasma TNF-alpha and IL-6 concentrations between patients with and without ECG or ECHO changes. During the follow-up, all acute-phase changes in ECG and ECHO reverted to normal, which probably reflects their benign nature. We conclude that abnormal cardiac findings are surprisingly common during NE.}, author = {Makela, Satu and Kokkonen, Liisa and Ala-Houhala, Ilpo and Groundstroem, Kaj and Harmoinen, Aimo and Huhtala, Heini and Hurme, Mikko and Paakkala, Antti and Porsti, Ilkka and Virtanen, Vesa and Vaheri, Antti and Mustonen, Jukka}, citeulike-article-id = {3445866}, citeulike-linkout-0 = {http://dx.doi.org/10.1080/00365540802502629}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18932105}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18932105}, day = {19}, doi = {10.1080/00365540802502629}, issn = {0036-5548}, journal = {Scandinavian journal of infectious diseases}, month = {October}, pages = {1--6}, posted-at = {2008-10-24 08:17:25}, priority = {2}, title = {More than half of the patients with acute Puumala hantavirus infection have abnormal cardiac findings.}, url = {http://dx.doi.org/10.1080/00365540802502629}, year = {2008} }

TY - JOUR ID - citeulike:3445866 L3 - citeulike-article-id:3445866 N2 - This study was conducted to determine the frequency, severity and outcome of cardiac findings in patients with acute Puumala hantavirus-induced nephropathia epidemica (NE). 70 consecutive, hospital-treated patients with serologically confirmed NE were prospectively examined using serial electrocardiograms (ECG), plasma troponin I, tumour necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), and echocardiography (ECHO). Examinations were repeated after 3 and 12 months. ECG changes were observed in 57% of patients. Plasma troponin I levels remained normal in all. In six patients, ECHO showed left ventricular contraction abnormalities, and 1 patient had mild pericardial effusion. There were no differences in clinical or standard laboratory findings or in plasma TNF-alpha and IL-6 concentrations between patients with and without ECG or ECHO changes. During the follow-up, all acute-phase changes in ECG and ECHO reverted to normal, which probably reflects their benign nature. We conclude that abnormal cardiac findings are surprisingly common during NE. JF - Scandinavian journal of infectious diseases SN - 0036-5548 EP - 6 TI - More than half of the patients with acute Puumala hantavirus infection have abnormal cardiac findings. SP - 1 AU - Makela, Satu AU - Kokkonen, Liisa AU - Ala-Houhala, Ilpo AU - Groundstroem, Kaj AU - Harmoinen, Aimo AU - Huhtala, Heini AU - Hurme, Mikko AU - Paakkala, Antti AU - Porsti, Ilkka AU - Virtanen, Vesa AU - Vaheri, Antti AU - Mustonen, Jukka PY - 2008/10/19/ UR - http://dx.doi.org/10.1080/00365540802502629 ER -