Prospective associations of early-onset Axis I disorders with developing eating disorders. Export

@article{citeulike:3773684, abstract = {OBJECTIVE: The purpose of this study is to analyze the developmental relationships of adolescent-onset Axis I mental disorders and eating disorders (EDs). METHOD: One thousand three hundred eighteen adolescent twins born from 1983 to 1987 completed a professionally administered semistructured psychiatric interview at the age of 14 years and a questionnaire follow-up at the age of 17.5 years. RESULTS: Eating disorders at the age of 17.5 years were significantly predicted by major depressive disorder (odds ratio, 5.9; 95\% confidence interval, 2.6-15.3) and generalized anxiety disorder (GAD) (odds ratio, 4.7; 95\% confidence interval, 1.8-15.6) at the age of 14 years, when baseline EDs were excluded. Early-onset major depressive disorder in combination with GAD increased the likelihood of developing EDs compared with either mood or anxiety disorders alone. Similar risks and trends were evident in within-family analyses of twin pairs discordant for baseline predictors and ED outcome. CONCLUSIONS: Depressive disorder and GAD that manifest at that age of 14 years predict future EDs. Analysis of discordant twins suggested that early-onset depressive disorder and GAD prospectively relate to EDs in adolescence, even after familial factors are taken into account.}, author = {Sihvola, E. and Keski-Rahkonen, A. and Dick, D. M. and Hoek, H. W. and Raevuori, A. and Rose, R. J. and Pulkkinen, L. and Marttunen, M. and Kaprio, J.}, citeulike-article-id = {3773684}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.comppsych.2008.05.004}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19059509}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19059509}, doi = {10.1016/j.comppsych.2008.05.004}, issn = {1532-8384}, journal = {Comprehensive psychiatry}, number = {1}, pages = {20--25}, posted-at = {2008-12-11 13:37:08}, priority = {2}, title = {Prospective associations of early-onset Axis I disorders with developing eating disorders.}, url = {http://dx.doi.org/10.1016/j.comppsych.2008.05.004}, volume = {50}, year = {2009} }

TY - JOUR ID - citeulike:3773684 L3 - citeulike-article-id:3773684 N2 - OBJECTIVE: The purpose of this study is to analyze the developmental relationships of adolescent-onset Axis I mental disorders and eating disorders (EDs). METHOD: One thousand three hundred eighteen adolescent twins born from 1983 to 1987 completed a professionally administered semistructured psychiatric interview at the age of 14 years and a questionnaire follow-up at the age of 17.5 years. RESULTS: Eating disorders at the age of 17.5 years were significantly predicted by major depressive disorder (odds ratio, 5.9; 95% confidence interval, 2.6-15.3) and generalized anxiety disorder (GAD) (odds ratio, 4.7; 95% confidence interval, 1.8-15.6) at the age of 14 years, when baseline EDs were excluded. Early-onset major depressive disorder in combination with GAD increased the likelihood of developing EDs compared with either mood or anxiety disorders alone. Similar risks and trends were evident in within-family analyses of twin pairs discordant for baseline predictors and ED outcome. CONCLUSIONS: Depressive disorder and GAD that manifest at that age of 14 years predict future EDs. Analysis of discordant twins suggested that early-onset depressive disorder and GAD prospectively relate to EDs in adolescence, even after familial factors are taken into account. IS - 1 JF - Comprehensive psychiatry SN - 1532-8384 EP - 25 TI - Prospective associations of early-onset Axis I disorders with developing eating disorders. VL - 50 SP - 20 AU - Sihvola, E AU - Keski-Rahkonen, A AU - Dick, DM AU - Hoek, HW AU - Raevuori, A AU - Rose, RJ AU - Pulkkinen, L AU - Marttunen, M AU - Kaprio, J PY - 2009///b UR - http://dx.doi.org/10.1016/j.comppsych.2008.05.004 ER -