Adult Stature and Diabetes Complications in Patients With Type 1 Diabetes Export

@article{citeulike:4785354, abstract = {10.2337/db08-1767 Short adult stature has previously been associated with cardiovascular disease, but its relationship with the microvascular complications of diabetes is uncertain. Therefore, we evaluated the association between adult stature and prevalence and incidence of diabetic microvascular complications. This cross-sectional and longitudinal study comprises 3,968 adult patients with type 1 diabetes from the Finnish Diabetic Nephropathy (FinnDiane) Study and 1,246 adult patients from the Diabetes Control and Complications Trial (DCCT). In FinnDiane, diabetic nephropathy was defined as urinary albumin excretion ≥300 mg/24 h, dialysis, or renal transplantation. Retinopathy was divided into background and proliferative (laser-treated) retinopathy. In the DCCT, original nephropathy (class 1–6) and retinopathy (Early Treatment of Diabetic Retinopathy Study) classifications were used. In the FinnDiane study, patients in the lowest quartile of adult height had increased risks of prevalent diabetic nephropathy (odds ratio [OR] 1.71, 95\% CI 1.44–2.02) and prevalent laser-treated retinopathy (1.66, 1.43–1.93) compared with other patients. Similarly, in the DCCT, patients in the lowest quartile of adult height had increased risks of incident diabetic nephropathy class 4–6 (hazard ratio 2.70, 95\% CI 1.59–4.59) and incident proliferative retinopathy (2.06, 1.15–3.71). In the FinnDiane study, the associations were largely explained by childhood exposure to diabetes. However, in the DCCT, where a greater proportion of patients had diabetes onset >18 years, the association with nephropathy was independent of childhood diabetes exposure. Short adult stature is associated with microvascular complications in patients with type 1 diabetes. These findings are compatible with either childhood diabetes exposure or ” common soil” or both as potential explanations.}, author = {Wad\'{e}n, Johan and Forsblom, Carol and Thorn, Lena M. and Saraheimo, Markku and Roseng\r{a}rd-B\"{a}rlund, Milla and Heikkil\"{a}, Outi and Hietala, Kustaa and Ong, Ken and Wareham, Nicholas and Groop, Per-Henrik}, citeulike-article-id = {4785354}, citeulike-linkout-0 = {http://dx.doi.org/10.2337/db08-1767}, citeulike-linkout-1 = {http://diabetes.diabetesjournals.org/content/58/8/1914.abstract}, citeulike-linkout-2 = {http://diabetes.diabetesjournals.org/content/58/8/1914.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19491208}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19491208}, day = {2}, doi = {10.2337/db08-1767}, issn = {1939-327X}, journal = {Diabetes}, month = {August}, number = {8}, pages = {1914--1920}, posted-at = {2009-06-09 10:17:22}, priority = {2}, title = {Adult Stature and Diabetes Complications in Patients With Type 1 Diabetes}, url = {http://dx.doi.org/10.2337/db08-1767}, volume = {58}, year = {2009} }

TY - JOUR ID - citeulike:4785354 L3 - citeulike-article-id:4785354 N2 - 10.2337/db08-1767 Short adult stature has previously been associated with cardiovascular disease, but its relationship with the microvascular complications of diabetes is uncertain. Therefore, we evaluated the association between adult stature and prevalence and incidence of diabetic microvascular complications. This cross-sectional and longitudinal study comprises 3,968 adult patients with type 1 diabetes from the Finnish Diabetic Nephropathy (FinnDiane) Study and 1,246 adult patients from the Diabetes Control and Complications Trial (DCCT). In FinnDiane, diabetic nephropathy was defined as urinary albumin excretion ≥300 mg/24 h, dialysis, or renal transplantation. Retinopathy was divided into background and proliferative (laser-treated) retinopathy. In the DCCT, original nephropathy (class 1–6) and retinopathy (Early Treatment of Diabetic Retinopathy Study) classifications were used. In the FinnDiane study, patients in the lowest quartile of adult height had increased risks of prevalent diabetic nephropathy (odds ratio [OR] 1.71, 95% CI 1.44–2.02) and prevalent laser-treated retinopathy (1.66, 1.43–1.93) compared with other patients. Similarly, in the DCCT, patients in the lowest quartile of adult height had increased risks of incident diabetic nephropathy class 4–6 (hazard ratio 2.70, 95% CI 1.59–4.59) and incident proliferative retinopathy (2.06, 1.15–3.71). In the FinnDiane study, the associations were largely explained by childhood exposure to diabetes. However, in the DCCT, where a greater proportion of patients had diabetes onset >18 years, the association with nephropathy was independent of childhood diabetes exposure. Short adult stature is associated with microvascular complications in patients with type 1 diabetes. These findings are compatible with either childhood diabetes exposure or “common soil” or both as potential explanations. IS - 8 JF - Diabetes SN - 1939-327X EP - 1920 TI - Adult Stature and Diabetes Complications in Patients With Type 1 Diabetes VL - 58 SP - 1914 AU - Wadén, Johan AU - Forsblom, Carol AU - Thorn, Lena AU - Saraheimo, Markku AU - Rosengård-Bärlund, Milla AU - Heikkilä, Outi AU - Hietala, Kustaa AU - Ong, Ken AU - Wareham, Nicholas AU - Groop, Per-Henrik PY - 2009/08/02/ UR - http://dx.doi.org/10.2337/db08-1767 ER -