Low calcium:phosphorus ratio in habitual diets affects serum parathyroid hormone concentration and calcium metabolism in healthy women with adequate calcium intake. Export

@article{citeulike:5908822, abstract = {Excessive dietary P intake alone can be deleterious to bone through increased parathyroid hormone (PTH) secretion, but adverse effects on bone increase when dietary Ca intake is low. In many countries, P intake is abundant, whereas Ca intake fails to meet recommendations; an optimal dietary Ca:P ratio is therefore difficult to achieve. Our objective was to investigate how habitual dietary Ca:P ratio affects serum PTH (S-PTH) concentration and other Ca metabolism markers in a population with generally adequate Ca intake. In this cross-sectional analysis of 147 healthy women aged 31-43 years, fasting blood samples and three separate 24-h urinary samples were collected. Participants kept a 4-d food record and were divided into quartiles according to their dietary Ca:P ratios. The 1st quartile with Ca:P molar ratio </= 0.50 differed significantly from the 2nd (Ca:P molar ratio 0.51-0.57), 3rd (Ca:P molar ratio 0.58-0.64) and 4th (Ca:P molar ratio >/= 0.65) quartiles by interfering with Ca metabolism. In the 1st quartile, mean S-PTH concentration (P = 0.021) and mean urinary Ca (U-Ca) excretion were higher (P = 0.051) than in all other quartiles. These findings suggest that in habitual diets low Ca:P ratios may interfere with homoeostasis of Ca metabolism and increase bone resorption, as indicated by higher S-PTH and U-Ca levels. Because low habitual dietary Ca:P ratios are common in Western diets, more attention should be focused on decreasing excessively high dietary P intake and increasing Ca intake to the recommended level.}, author = {Kemi, Virpi E. and K\"{a}rkk\"{a}inen, Merja U. and Rita, Hannu J. and Laaksonen, Marika M. and Outila, Terhi A. and Lamberg-Allardt, Christel J.}, citeulike-article-id = {5908822}, citeulike-linkout-0 = {http://dx.doi.org/10.1017/S0007114509992121}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19781123}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19781123}, day = {28}, doi = {10.1017/S0007114509992121}, issn = {1475-2662}, journal = {The British journal of nutrition}, month = {September}, pages = {1--8}, posted-at = {2009-10-08 09:22:33}, priority = {2}, title = {Low calcium:phosphorus ratio in habitual diets affects serum parathyroid hormone concentration and calcium metabolism in healthy women with adequate calcium intake.}, url = {http://dx.doi.org/10.1017/S0007114509992121}, year = {2009} }

TY - JOUR ID - citeulike:5908822 L3 - citeulike-article-id:5908822 N2 - Excessive dietary P intake alone can be deleterious to bone through increased parathyroid hormone (PTH) secretion, but adverse effects on bone increase when dietary Ca intake is low. In many countries, P intake is abundant, whereas Ca intake fails to meet recommendations; an optimal dietary Ca:P ratio is therefore difficult to achieve. Our objective was to investigate how habitual dietary Ca:P ratio affects serum PTH (S-PTH) concentration and other Ca metabolism markers in a population with generally adequate Ca intake. In this cross-sectional analysis of 147 healthy women aged 31-43 years, fasting blood samples and three separate 24-h urinary samples were collected. Participants kept a 4-d food record and were divided into quartiles according to their dietary Ca:P ratios. The 1st quartile with Ca:P molar ratio </= 0.50 differed significantly from the 2nd (Ca:P molar ratio 0.51-0.57), 3rd (Ca:P molar ratio 0.58-0.64) and 4th (Ca:P molar ratio >/= 0.65) quartiles by interfering with Ca metabolism. In the 1st quartile, mean S-PTH concentration (P = 0.021) and mean urinary Ca (U-Ca) excretion were higher (P = 0.051) than in all other quartiles. These findings suggest that in habitual diets low Ca:P ratios may interfere with homoeostasis of Ca metabolism and increase bone resorption, as indicated by higher S-PTH and U-Ca levels. Because low habitual dietary Ca:P ratios are common in Western diets, more attention should be focused on decreasing excessively high dietary P intake and increasing Ca intake to the recommended level. JF - The British journal of nutrition SN - 1475-2662 EP - 8 TI - Low calcium:phosphorus ratio in habitual diets affects serum parathyroid hormone concentration and calcium metabolism in healthy women with adequate calcium intake. SP - 1 AU - Kemi, Virpi AU - Kärkkäinen, Merja AU - Rita, Hannu AU - Laaksonen, Marika AU - Outila, Terhi AU - Lamberg-Allardt, Christel PY - 2009/09/28/ UR - http://dx.doi.org/10.1017/S0007114509992121 ER -