Efficiency of working memory encoding in twins discordant for schizophrenia. Export

@article{citeulike:6042251, abstract = {It has been proposed that patients with schizophrenia and some of their relatives suffer from reduced neurocognitive efficiency, increasing their sensitivity to experimental task demands. The present study evaluated such a possibility during performance of a working memory task by schizophrenia patients and their co-twins along with a healthy control sample. Electrophysiological data were obtained from sets of nine twin pairs (monozygotic and dizygotic pairs collapsed) discordant for a diagnosis of schizophrenia and from nine matched healthy control twin pairs, during administration of a variable-load spatial working memory task. Event-related potentials (ERPs) were measured immediately after memory set onset and during a delay period. For correctly performed trials, slow-wave ERP activity measured during the late stimulus encoding and delay periods exhibited a significant Diagnostic Group-by-Memory Load interaction, with schizophrenia patients showing a differentially strong load effect. Patients' co-twins displayed an intermediate level of load sensitivity while healthy controls showed no significant load effect. These results support an inefficiency model of neurocognitive dysfunction in schizophrenia, a pattern that appears to be related to the pathogenesis and inheritance of the disorder. Furthermore, this inefficiency appeared during the late stimulus encoding stage of working memory functioning, possibly reflecting disruptions in stimulus representation consolidation.}, author = {Bachman, Peter and Kim, Junghoon and Yee, Cindy M. and Therman, Sebastian and Manninen, Marko and L\"{o}nnqvist, Jouko and Kaprio, Jaakko and Huttunen, Matti O. and N\"{a}\"{a}t\"{a}nen, Risto and Cannon, Tyrone D.}, citeulike-article-id = {6042251}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.pscychresns.2009.04.010}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19853415}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19853415}, day = {21}, doi = {10.1016/j.pscychresns.2009.04.010}, issn = {0165-1781}, journal = {Psychiatry research}, month = {October}, posted-at = {2009-10-30 11:55:03}, priority = {2}, title = {Efficiency of working memory encoding in twins discordant for schizophrenia.}, url = {http://dx.doi.org/10.1016/j.pscychresns.2009.04.010}, year = {2009} }

TY - JOUR ID - citeulike:6042251 L3 - citeulike-article-id:6042251 N2 - It has been proposed that patients with schizophrenia and some of their relatives suffer from reduced neurocognitive efficiency, increasing their sensitivity to experimental task demands. The present study evaluated such a possibility during performance of a working memory task by schizophrenia patients and their co-twins along with a healthy control sample. Electrophysiological data were obtained from sets of nine twin pairs (monozygotic and dizygotic pairs collapsed) discordant for a diagnosis of schizophrenia and from nine matched healthy control twin pairs, during administration of a variable-load spatial working memory task. Event-related potentials (ERPs) were measured immediately after memory set onset and during a delay period. For correctly performed trials, slow-wave ERP activity measured during the late stimulus encoding and delay periods exhibited a significant Diagnostic Group-by-Memory Load interaction, with schizophrenia patients showing a differentially strong load effect. Patients' co-twins displayed an intermediate level of load sensitivity while healthy controls showed no significant load effect. These results support an inefficiency model of neurocognitive dysfunction in schizophrenia, a pattern that appears to be related to the pathogenesis and inheritance of the disorder. Furthermore, this inefficiency appeared during the late stimulus encoding stage of working memory functioning, possibly reflecting disruptions in stimulus representation consolidation. JF - Psychiatry research SN - 0165-1781 TI - Efficiency of working memory encoding in twins discordant for schizophrenia. AU - Bachman, Peter AU - Kim, Junghoon AU - Yee, Cindy AU - Therman, Sebastian AU - Manninen, Marko AU - Lönnqvist, Jouko AU - Kaprio, Jaakko AU - Huttunen, Matti AU - Näätänen, Risto AU - Cannon, Tyrone PY - 2009/10/21/ UR - http://dx.doi.org/10.1016/j.pscychresns.2009.04.010 ER -