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Stroke; a journal of cerebral circulation (4 March 2010)
by Reinhold Schmidt, Stefan Ropele, José Ferro, et al.Sofia Madureira, Ana Verdelho, Katja Petrovic, Alida Gouw, Wiesje M. van der Flier, Christian Enzinger, Leonardo Pantoni, Domenico Inzitari, Timo Erkinjuntti, Philip Scheltens, Lars O. Wahlund, Gunhild Waldemar, Egill Rostrup, Anders Wallin, Frederik Barkhof, Franz Fazekas, on behalf of the LADIS study group
Abstract
BACKGROUND AND PURPOSE: The mechanisms by which leukoariosis impacts on clinical and cognitive functions are not yet fully understood. We hypothesized that ultrastructural abnormalities of the normal-appearing brain tissue (NABT) assessed by diffusion-weighted imaging played a major and independent role. METHODS: In addition to a comprehensive clinical, neuropsychologic, and imaging work-up, diffusion-weighted imaging was performed in 340 participants of the multicenter leukoariosis and disability study examining the impact of white matter hyperintensities (WMH) on 65- to 85-year old individuals without previous ...
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Psychological medicine (12 August 2009), pp. 1-8.
by A. Teodorczuk, M. J. Firbank, L. Pantoni, et al.A. Poggesi, T. Erkinjuntti, A. Wallin, L-O O. Wahlund, P. Scheltens, G. Waldemar, G. Schrotter, J. M. Ferro, H. Chabriat, H. Bazner, M. Visser, D. Inzitari, J. T. O'Brien
Abstract
BACKGROUND: Growing evidence suggests that cerebral white-matter changes and depressive symptoms are linked directly along the causal pathway. We investigated whether baseline severity of cerebral white-matter changes predict longer-term future depressive outcomes in a community sample of non-disabled older adults.MethodIn the Leukoaraiosis and Disability in the Elderly (LADIS) study, a longitudinal multi-centre pan-European study, 639 older subjects underwent baseline structural magnetic resonance imaging (MRI) and clinical assessments. Baseline severity of white-matter changes was quantified volumetrically. Depressive outcomes were assessed in terms ...
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BMJ (Clinical research ed.), Vol. 339 (2009)
by Domenico Inzitari, Giovanni Pracucci, Anna Poggesi, et al.Giovanna Carlucci, Frederik Barkhof, Hugues Chabriat, Timo Erkinjuntti, Franz Fazekas, José M. Ferro, Michael Hennerici, Peter Langhorne, John O'Brien, Philip Scheltens, Marieke C. Visser, Lars-Olof O. Wahlund, Gunhild Waldemar, Anders Wallin, Leonardo Pantoni, LADIS Study Group
Abstract
OBJECTIVE: To assess the impairment in daily living activities in older people with age related changes in white matter according to the severity of these changes. DESIGN: Observational data collection and follow-up of a cohort of older people undergoing brain magnetic resonance imaging after non-disabling complaints. SETTING: 11 European centres. PARTICIPANTS: 639 non-disabled older patients (mean age 74.1 (SD 5.0), 45.1% men) in whom brain magnetic resonance imaging showed mild, moderate, or severe age related changes in white matter (Fazekas scale). ...
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Cerebrovascular diseases (Basel, Switzerland), Vol. 27, No. 4. (10 March 2009), pp. 384-391.
by Hanna Jokinen, Hely Kalska, Raija Ylikoski, et al.Sofia Madureira, Ana Verdelho, Wiesje M M. van der Flier, Philip Scheltens, Frederik Barkhof, Marieke C C. Visser, Franz Fazekas, Reinhold Schmidt, John O'Brien, Gunhild Waldemar, Anders Wallin, Hugues Chabriat, Leonardo Pantoni, Domenico Inzitari, Timo Erkinjuntti
Abstract
Background: Cross-sectional studies have indicated that subcortical ischemic vascular disease (SIVD), as defined according to imaging criteria, is associated with a specific clinical and cognitive profile. Much less is known about the long-term cognitive consequences of SIVD. The aim of the study was to investigate the longitudinal cognitive performance and incident dementia in subjects with and without SIVD in a sample of older adults with white matter lesions. Methods: In the Leukoaraiosis and Disability (LADIS) study, 639 participants were examined with ...
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Cerebrovascular diseases (Basel, Switzerland), Vol. 27, No. 4. (14 February 2009), pp. 336-344.
by Hanna Jokinen, Hely Kalska, Raija Ylikoski, et al.Sofia Madureira, Ana Verdelho, Alida Gouw, Philip Scheltens, Frederik Barkhof, Marieke C C. Visser, Franz Fazekas, Reinhold Schmidt, John O'Brien, Michael Hennerici, Hansjorg Baezner, Gunhild Waldemar, Anders Wallin, Hugues Chabriat, Leonardo Pantoni, Domenico Inzitari, Timo Erkinjuntti
Abstract
Background: Subcortical ischemic vascular disease (SIVD) is a common, but often overlooked cause of vascular cognitive impairment. Diagnostic research criteria for SIVD are based on magnetic resonance imaging (MRI) findings including substantial white matter lesions (WML) and multiple lacunar infarcts. Empirical studies validating these imaging criteria are still few. The purpose of the study was to describe the clinical and cognitive characteristics of the MRI-defined SIVD in a mixed sample of functionally independent elderly subjects with WML. Methods: The subjects of ...
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J Neurol Neurosurg Psychiatry, Vol. 80, No. 6. (1 June 2009), pp. 608-613.
by C. Blahak, H. Baezner, L. Pantoni, et al.A. Poggesi, H. Chabriat, T. Erkinjuntti, F. Fazekas, J. M. Ferro, P. Langhorne, J. O'Brien, M. C. Visser, L. O. Wahlund, G. Waldemar, A. Wallin, D. Inzitari, M. G. Hennerici, on behalf of the LADIS Study Group
Abstract
BackgroundGlobal age related white matter changes (ARWMC) are associated with progressive gait disturbances and falls, hypothesised to result from interruptions of cortico-subcortical circuits controlling balance, posture and locomotion. MethodsThe location of ARWMC in a large cohort of elderly non-disabled individuals with reported falls was analysed, using the cross sectional data of the Leukoaraiosis and Disability (LADIS) study. Detailed anatomical distributions of ARWMC assessed by MRI studies were analysed with respect to falls and balance performance. ResultsThe severity of global ...
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Journal of magnetic resonance imaging : JMRI, Vol. 29, No. 2. (22 January 2009), pp. 268-274.
by Stefan Ropele, Alexandra Seewann, Alida A A. Gouw, et al.Wiesje M M. van der Flier, Reinhold Schmidt, Leonardo Pantoni, Domenico Inzitari, Timo Erkinjuntti, Philip Scheltens, Lars O O. Wahlund, Gunhild Waldemar, Hugues Chabriat, José Ferro, Michael Hennerici, John O'Brien, Anders Wallin, Peter Langhorne, Marieke C C. Visser, Frederik Barkhof, Franz Fazekas,
Abstract
PURPOSE: To explore the value of diffusion-weighted imaging (DWI) and magnetization transfer imaging (MTI) for the improved detection and quantification of cerebral tissue changes associated with ageing and white matter hyperintensities (WMH). MATERIALS AND METHODS: DWI (n = 340) and MTI (n = 177) were performed in nine centers of the multinational Leukoaraiosis And DISability (LADIS) study investigating the impact of WMH on 65- to 85-year-old individuals without prior disability. We assessed the apparent diffusion coefficient (ADC) and magnetization transfer ratio ...
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Stroke; a journal of cerebral circulation (14 August 2008)
by Alida A A. Gouw, Wiesje M M. van der Flier, Leonardo Pantoni, et al.Domenico Inzitari, Timo Erkinjuntti, Lars O O. Wahlund, Gunhild Waldemar, Reinhold Schmidt, Franz Fazekas, Philip Scheltens, Frederik Barkhof,
Abstract
BACKGROUND AND PURPOSE: We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period. METHODS: Baseline and 3-year follow-up MRI were collected within the LADIS study (n=358). Incident lacunes were characterized with respect to brain region, their appearance within pre-existent white matter hyperintensities (WMH), surrounding WMH size, and risk factors. RESULTS: 106 incident lacunes were observed in 62 patients (58 subcortical white matter [WM], 35 basal ganglia, and 13 infratentorial). Incident subcortical WM lacunes ...
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Journal of the American Geriatrics Society (4 August 2008)
by Anna Poggesi, Giovanni Pracucci, Hugues Chabriat, et al.Timo Erkinjuntti, Franz Fazekas, Ana Verdelho, Michael Hennerici, Peter Langhorne, John O'Brien, Philip Scheltens, Marieke C C. Visser, Milita Crisby, Gunhild Waldemar, Anders Wallin, Domenico Inzitari, Leonardo Pantoni,
Abstract
OBJECTIVES: To investigate, in a cohort of nondisabled elderly people, the association between urinary complaints and severity of age-related white matter changes (ARWMC). DESIGN: Cross-sectional data analysis from a longitudinal multinational study. SETTING: The Leukoaraiosis And DISability Study, assessing ARWMC as an independent predictor of the transition from functional autonomy to disability in elderly subjects. PARTICIPANTS: Six hundred thirty-nine subjects (288 men, 351 women, mean age 74.1+/-5.0) with magnetic resonance imaging (MRI)-detected ARWMC of different severity. MEASUREMENTS: ARWMC severity was graded ...
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AJNR. American journal of neuroradiology (12 June 2008)
by C Ryberg, E Rostrup, K Sjöstrand, et al.O B B. Paulson, F Barkhof, P Scheltens, E C W C. van Straaten, F Fazekas, R Schmidt, T Erkinjuntti, L-O O. Wahlund, A M M. Basile, L Pantoni, D Inzitari, G Waldemar,
Abstract
BACKGROUND AND PURPOSE: The corpus callosum (CC) is the most important structure involved in the transmission of interhemispheric information. The aim of this study was to investigate the potential correlation between regional age-related white matter changes (ARWMC) and atrophy of CC in elderly subjects. MATERIALS AND METHODS: In 578 subjects with ARWMC from the Leukoaraiosis And DISability (LADIS) study, the cross-sectional area of the CC was automatically segmented on the normalized midsagittal MR imaging section and subdivided into 5 regions. The ...
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NeuroImage (29 February 2008)
by Tim B B. Dyrby, Egill Rostrup, William F C F. Baaré, et al.Elisabeth C W C. van Straaten, Frederik Barkhof, Hugo Vrenken, Stefan Ropele, Reinhold Schmidt, Timo Erkinjuntti, Lars-Olof O. Wahlund, Leonardo Pantoni, Domenico Inzitari, Olaf B B. Paulson, Lars Kai K. Hansen, Gunhild Waldemar,
Abstract
Age-related white matter changes (WMC) are thought to be a marker of vascular pathology, and have been associated with motor and cognitive deficits. In the present study, an optimized artificial neural network was used as an automatic segmentation method to produce probabilistic maps of WMC in a clinical multi-center study. The neural network uses information from T1- and T2-weighted and fluid attenuation inversion recovery (FLAIR) magnetic resonance (MR) scans, neighboring voxels and spatial location. Generalizability of the neural network was optimized ...
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Neurology, Vol. 70, No. 12. (18 March 2008), pp. 935-942.
by H. Baezner, C. Blahak, A. Poggesi, et al.L. Pantoni, D. Inzitari, H. Chabriat, T. Erkinjuntti, F. Fazekas, J. M. Ferro, P. Langhorne, J. O'Brien, P. Scheltens, M. C. Visser, L. O. Wahlund, G. Waldemar, A. Wallin, M. G. Hennerici,
Abstract
OBJECTIVE: In the Leukoaraiosis and Disability (LADIS) Study, 11 European centers are evaluating the role of age-related white matter changes (ARWMC) as an independent determinant of the transition to disability in the elderly (65 to 84 years). We aimed at determining the influence of ARWMC on different objective measures of gait and balance. METHODS: Six hundred thirty-nine nondisabled individuals were prospectively enrolled and are being followed-up for 3 years. Subjects are graded in three standardized categories of ARWMC (mild, moderate, and ...
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Stroke (6 March 2008)
by Alida A A. Gouw, Wiesje M M. van der Flier, Franz Fazekas, et al.Elisabeth C W C. van Straaten, Leonardo Pantoni, Anna Poggesi, Domenico Inzitari, Timo Erkinjuntti, Lars O O. Wahlund, Gunhild Waldemar, Reinhold Schmidt, Philip Scheltens, Frederik Barkhof,
Abstract
BACKGROUND AND PURPOSE: We studied the natural course of white matter hyperintensities (WMH) and lacunes, the main MRI representatives of small vessel disease, over time and evaluated possible predictors for their development. METHODS: Baseline and repeat MRI (3-year follow-up) were collected within the multicenter, multinational Leukoaraiosis and Disability study (n=396). Baseline WMH were scored on MRI by the Fazekas scale and the Scheltens scale. WMH progression was assessed using the modified Rotterdam Progression scale (absence/presence of progression in 9 brain regions). ...
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Cerebrovasc Dis, Vol. 25, No. 3. (24 January 2008), pp. 247-253.
by A A A. Gouw, W M M. van der Flier, E C W C. van Straaten, et al.L Pantoni, A J J. Bastos-Leite, D Inzitari, T Erkinjuntti, L O O. Wahlund, C Ryberg, R Schmidt, F Fazekas, P Scheltens, F Barkhof
Abstract
Background: Investigating associations between the change of white matter hyperintensities (WMH) and clinical symptoms over time is crucial for establishing a causal relationship. However, the most suitable method for measuring WMH progression has not been established yet. We compared the reliability and sensitivity of cross-sectional and longitudinal visual scales with volumetry for measuring WMH progression. Methods: Twenty MRI scan pairs (interval 2 years) were included from the Amsterdam center of the LADIS study. Semi-automated volumetry of WMH was performed twice by ...
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J Neurol Neurosurg Psychiatry (12 December 2007)
by Bruno Miranda, Sofia Madureira, Ana Verdelho, et al.José M M. Ferro, Leonardo Pantoni, Emilia Salvadori, Hugues Chabriat, Timo Erkinjuntti, Franz Fazekas, Michael Hennerici, John O'Brien, Philip Scheltens, Marieke C C. Visser, Lars-Olof O. Wahlund, Gunhild Waldemar, Anders Wallin, Domenico Inzitari
Abstract
OBJECTIVES: To determine whether self-perceived memory impairment is associated with the severity of white matter changes (WMC) and is related to cognitive impairment. METHODS: Data were drawn from the multinational leukoaraiosis and disability (LADIS) study which investigates the impact of WMC on global functioning. WMC severity was rated using the Fazekas scale. Medial temporal lobe atrophy (MTA) was scored visually and values were meaned. The neuropsychological battery consisted of the Mini-Mental State Examination, a modified version of the VADAS-Cog, Trail making ...
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Br J Psychiatry, Vol. 191 (September 2007), pp. 212-217.
by A Teodorczuk, J T T. O'brien, M J J. Firbank, et al.L Pantoni, A Poggesi, T Erkinjuntti, A Wallin, L-O O. Wahlund, A Gouw, G Waldemar, R Schmidt, J M M. Ferro, H Chabriat, H Bäzner, D Inzitari,
Abstract
BACKGROUND: Evidence from cross-sectional studies suggests a link between cerebral age-related white matter changes and depressive symptoms in older people, although the temporal association remains unclear. AIMS: To investigate age-related white matter changes on magnetic resonance imaging (MRI) as an independent predictor of depressive symptoms at 1 year after controlling for known confounders. METHOD: In a pan-European multicentre study of 639 older adults without significant disability, MRI white matter changes and demographic and clinical variables, including cognitive scores, quality of life, ...
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Dement Geriatr Cogn Disord, Vol. 24, No. 2. (12 June 2007), pp. 73-81.
by Raija Ylikoski, Hanna Jokinen, Pia Andersen, et al.Oili Salonen, Sofia Madureira, Jose Ferro, Frederik Barkhof, Wiesje van der Flier, Reinhold Schmidt, Franz Fazekas, Philip Scheltens, Gunhild Waldemar, Emilia Salvadori, Leonardo Pantoni, Domenico Inzitari, Timo Erkinjuntti
Abstract
Background/Aims: The Alzheimer's Disease Assessment Scale cognitive subscale (ADAS-cog) is a widely used rating instrument. The Vascular Dementia Assessment Scale cognitive subscale (VADAS-cog) includes additional tests reflecting mental speed and executive functions. The objective of this study was to compare the results of the two scales among subjects with various degrees of white matter hyperintensities (WMHs). Methods:In the multicentre, multinational Leukoaraiosis and Disability in the Elderly (LADIS) study, 616 non-disabled subjects between the ages of 65 and 84 were examined using ...
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J Neurol Neurosurg Psychiatry (30 April 2007)
by Ana Verdelho, Sofia Madureira, José M M. Ferro, et al.Anna-Maria M. Basile, Hugues Chabriat C. Chabriat, Timo Erkinjuntti, Franz Fazekas, Michael Md M. Hennerici, John O'brien, Leonardo Pantoni, Emilia Salvadori, Philip Scheltens, Marieke C C. Visser, Lars-Olof O. Wahlund, Gunhild Gunhild Waldemar, Anders Wallin, Domenico Inzitari
Abstract
Background and Purpose: Age-related white matter changes (ARWMC) are frequent in non-demented old subjects and are associated with impaired cognitive function. We aim to study the influence of vascular risk factors and ARWMC on the neuropsychological performance of an independent elderly population, namely if vascular risk factors impair cognition in addition to the effect of ARWMC. METHODS: Independent subjects with 65 to 84 years old with any degree of ARWMC were assessed using a comprehensive neuropsychological battery that included MMSE, VADAS-Cog, ...
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Arch Intern Med, Vol. 167, No. 1. (8 January 2007), pp. 81-88.
by D. Inzitari, M. Simoni, G. Pracucci, et al.A. Poggesi, A. M. Basile, H. Chabriat, T. Erkinjuntti, F. Fazekas, J. M. Ferro, M. Hennerici, P. Langhorne, J. O'brien, F. Barkhof, M. C. Visser, L. O. Wahlund, G. Waldemar, A. Wallin, L. Pantoni
Abstract
BACKGROUND: Age-related white matter changes (ARWMCs), frequently detected on neuroimaging, are associated with motor, cognitive, urinary, and mood disorders. The LADIS (LeukoAraiosis and DISability) Study primarily aims to assess ARWMCs as a determinant of global functional decline in the elderly population. METHODS: We enrolled 639 patients (mean age, 74.1 +/- 5.0 years; 45.1% male) referred for nondisabling complaints, who had ARWMCs detected on brain magnetic resonance imaging (MRI) of mild, moderate, or severe grade according to the Fazekas scale. At the ...
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J Neurol Neurosurg Psychiatry (6 October 2006)
by Hanna Jokinen, Charlotte Ryberg, Hely Kalska, et al.Raija Ylikoski, Egill Rostrup, Mikkel B B. Stegmann, Gunhild Waldemar, Sofia Madureira, Jose M M. Ferro, Elizabeth Cw C. van Straaten, Philip Scheltens, Frederik Barkhof, Franz Fazekas, Reinhold Schmidt, Giovanna Carlucci, Leonardo Pantoni, Domenico Inzitari, Timo Erkinjuntti
Abstract
Background and Purpose: Previous research has indicated that corpus callosum (CC) atrophy is associated with global cognitive decline in neurodegenerative diseases, but few studies have investigated specific cognitive functions. The purpose of the present study was to investigate the role of regional CC atrophy in mental speed, attention, and executive functions in subjects with age-related white matter hyperintensities (WMH). METHODS: In the Leukoaraiosis and Disability Study, 567 subjects with age-related WMH were examined with a detailed neuropsychological assessment and quantitative magnetic ...
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Am J Geriatr Psychiatry, Vol. 14, No. 10. (October 2006), pp. 834-841.
by John T T. O'brien, Michael J J. Firbank, Mani S S. Krishnan, et al.Elisabeth C W C. van Straaten, Wiesje M M. van der Flier, Katja Petrovic, Leonardo Pantoni, Michela Simoni, Timo Erkinjuntti, Anders Wallin, Lars-Olof O. Wahlund, Domenico Inzitari
Abstract
Objective: Both white matter hyperintensities (WMH) and lacunar infarcts have been associated with the development of depression in older subjects, although the relative importance of the two and the influence of lesion location and concomitant vascular disease are unclear. This study investigates the relationship between location and burden of WMH and lacunes on depressive features in older people. Method: In a pan-European multicenter study of 626 older subjects, the authors examined the relationship between regional magnetic resonance imaging white matter hyperintensities, ...
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Stroke (26 January 2006)
by Elisabeth C W C. van Straaten, Franz Fazekas, Egill Rostrup, et al.Philip Scheltens, Reinhold Schmidt, Leonardo Pantoni, Domenico Inzitari, Gunhild Waldemar, Timo Erkinjuntti, Riita Mäntylä, Lars-Olof O. Wahlund, Frederik Barkhof
Abstract
BACKGROUND AND PURPOSE: White matter hyperintensities (WMH) are associated with decline in cognition, gait, mood, and urinary continence. Associations may depend on the method used for measuring WMH. We investigated the ability of different WMH scoring methods to detect differences in WMH load between groups with and without symptoms. METHODS: We used data of 618 independently living elderly with WMH collected in the Leukoaraiosis And DISability (LADIS) study. Subjects with and without symptoms of depression, gait disturbances, urinary incontinence, and memory ...
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Stroke (1 September 2005)
by Wiesje M M. van der Flier, Elizabeth C W C. van Straaten, Frederik Barkhof, et al.Ana Verdelho, Sofia Madureira, Leonardo Pantoni, Domenico Inzitari, Timo Erkinjuntti, Militta Crisby, Gunhild Waldemar, Reinhold Schmidt, Franz Fazekas, Philip Scheltens
Abstract
BACKGROUND AND PURPOSE: On cerebral magnetic resonance imaging (MRI), white matter hyperintensities (WMH) and lacunes are generally viewed as evidence of small vessel disease. The clinical significance of small vessel disease in terms of global cognitive function has as yet not been completely clarified. We investigated the independent contribution of WMH and lacunes to general cognitive function in a group of independently living elderly with varying degrees of small vessel disease. METHODS: Data were drawn from the multicenter, multinational Leukokraurosis and ...
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