Discovery of Gene Function by Expression Profiling of the Malaria Parasite Life Cycle Export

@article{citeulike:740272, abstract = {The completion of the genome sequence for Plasmodium falciparum, the species responsible for most malaria human deaths, has the potential to reveal hundreds of new drug targets and proteins involved in pathogenesis. However, only [\~{}]35\% of the genes code for proteins with an identifiable function. The absence of routine genetic tools for studying Plasmodium parasites suggests that this number is unlikely to change quickly if conventional serial methods are used to characterize encoded proteins. Here, we use a high-density oligonucleotide array to generate expression profiles of human and mosquito stages of the malaria parasite's life cycle. Genes with highly correlated levels and temporal patterns of expression were often involved in similar functions or cellular processes. 10.1126/science.1087025}, author = {Le Roch, Karine G. and Zhou, Yingyao and Blair, Peter L. and Grainger, Muni and Moch, Kathleen J. and Haynes, David J. and De La and Holder, Anthony A. and Batalov, Serge and Carucci, Daniel J. and Winzeler, Elizabeth A.}, citeulike-article-id = {740272}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1087025}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/301/5639/1503}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/12893887}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=12893887}, doi = {10.1126/science.1087025}, journal = {Science}, keywords = {malaria, transcriptome}, month = {September}, number = {5639}, pages = {1503--1508}, posted-at = {2009-06-25 22:50:03}, priority = {0}, title = {Discovery of Gene Function by Expression Profiling of the Malaria Parasite Life Cycle}, url = {http://dx.doi.org/10.1126/science.1087025}, volume = {301}, year = {2003} }

TY - JOUR ID - citeulike:740272 L3 - citeulike-article-id:740272 N2 - The completion of the genome sequence for Plasmodium falciparum, the species responsible for most malaria human deaths, has the potential to reveal hundreds of new drug targets and proteins involved in pathogenesis. However, only [~]35% of the genes code for proteins with an identifiable function. The absence of routine genetic tools for studying Plasmodium parasites suggests that this number is unlikely to change quickly if conventional serial methods are used to characterize encoded proteins. Here, we use a high-density oligonucleotide array to generate expression profiles of human and mosquito stages of the malaria parasite's life cycle. Genes with highly correlated levels and temporal patterns of expression were often involved in similar functions or cellular processes. 10.1126/science.1087025 IS - 5639 JF - Science EP - 1508 TI - Discovery of Gene Function by Expression Profiling of the Malaria Parasite Life Cycle VL - 301 SP - 1503 KW - malaria KW - transcriptome AU - Le Roch, Karine AU - Zhou, Yingyao AU - Blair, Peter AU - Grainger, Muni AU - Moch, Kathleen AU - Haynes, David AU - De La AU - Holder, Anthony AU - Batalov, Serge AU - Carucci, Daniel AU - Winzeler, Elizabeth PY - 2003/09/12/ UR - http://dx.doi.org/10.1126/science.1087025 ER -