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Novel Approach to 3,4-Dihydro-2(1H)-quinolinone Derivatives via Cyclopropane Ring Expansion

by: Takayuki Tsuritani, Yuhei Yamamoto, Masashi Kawasaki, Toshiaki Mase
Org. Lett. In Organic Letters, Vol. 11, No. 5. (4 February 2009), pp. 1043-1045, doi:10.1021/ol802669r  Key: citeulike:11349529

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Abstract

N-(1?-Alkoxy)cyclopropyl-2-haloanilines are transformed to 3,4-dihydro-2(1H)-quinolinones via palladium-catalyzed cyclopropane ring expansion. The reaction tolerates a variety of functional groups such as ester, nitrile, ether, and ketone groups.


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