Quantification of brain mu-opioid receptors with [11C]carfentanil: reference-tissue methods. Export

@article{citeulike:2340688, abstract = {[(11)C]Carfentanil (CFN) is a mu-opioid agonist used for in vivo positron emission tomography (PET) studies of mu-opioid receptors. Previously, a tissue-ratio method was validated for the quantification of CFN binding. However, since that initial validation, several other blood independent (reference-tissue) methods have become available. To evaluate these methods, CFN PET studies with arterial blood sampling were acquired in six healthy male control subjects. Specific binding estimates obtained from reference-tissue methods were compared to those obtained with a more rigorous blood input modeling technique. It was determined that both a graphical method, and a simplified reference tissue model, were more accurate than the tissue-ratio method for quantification of CFN binding.}, address = {Department of Radiology, Johns Hopkins University, Baltimore, MD 21287, USA.}, author = {Endres, C. J. and Bencherif, B. and Hilton, J. and Madar, I. and Frost, J. J.}, citeulike-article-id = {2340688}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12623117}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12623117}, issn = {0969-8051}, journal = {Nucl Med Biol}, keywords = {carfentanil, human, kinetic\_modeling}, month = {February}, number = {2}, pages = {177--186}, posted-at = {2008-02-06 11:28:47}, priority = {0}, title = {Quantification of brain mu-opioid receptors with [11C]carfentanil: reference-tissue methods.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12623117}, volume = {30}, year = {2003} }

TY - JOUR ID - citeulike:2340688 L3 - citeulike-article-id:2340688 N2 - [(11)C]Carfentanil (CFN) is a mu-opioid agonist used for in vivo positron emission tomography (PET) studies of mu-opioid receptors. Previously, a tissue-ratio method was validated for the quantification of CFN binding. However, since that initial validation, several other blood independent (reference-tissue) methods have become available. To evaluate these methods, CFN PET studies with arterial blood sampling were acquired in six healthy male control subjects. Specific binding estimates obtained from reference-tissue methods were compared to those obtained with a more rigorous blood input modeling technique. It was determined that both a graphical method, and a simplified reference tissue model, were more accurate than the tissue-ratio method for quantification of CFN binding. IS - 2 JF - Nucl Med Biol SN - 0969-8051 AD - Department of Radiology, Johns Hopkins University, Baltimore, MD 21287, USA. EP - 186 TI - Quantification of brain mu-opioid receptors with [11C]carfentanil: reference-tissue methods. VL - 30 SP - 177 KW - carfentanil KW - human KW - kinetic_modeling AU - Endres, CJ AU - Bencherif, B AU - Hilton, J AU - Madar, I AU - Frost, JJ PY - 2003/02// UR - http://view.ncbi.nlm.nih.gov/pubmed/12623117 ER -